The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants
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The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. / Hartz, Annika; Pagel, Julia; Humberg, Alexander; Preuss, Michael; Schreiter, Lena; Rupp, Jan; Figge, Julia; Karsten, Christian M; Nürnberg, Peter; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph; German Neonatal Network (GNN).
in: PLOS ONE, Jahrgang 12, Nr. 5, 2017, S. e0178032.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants
AU - Hartz, Annika
AU - Pagel, Julia
AU - Humberg, Alexander
AU - Preuss, Michael
AU - Schreiter, Lena
AU - Rupp, Jan
AU - Figge, Julia
AU - Karsten, Christian M
AU - Nürnberg, Peter
AU - Herting, Egbert
AU - Göpel, Wolfgang
AU - Härtel, Christoph
AU - German Neonatal Network (GNN)
PY - 2017
Y1 - 2017
N2 - OBJECTIVES: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).METHODS: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.RESULTS: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.CONCLUSIONS: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.
AB - OBJECTIVES: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).METHODS: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.RESULTS: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.CONCLUSIONS: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.
KW - Cohort Studies
KW - Humans
KW - Infant, Newborn
KW - Infant, Very Low Birth Weight
KW - Infections/complications
KW - Mannose-Binding Lectin/deficiency
KW - Mannose-Binding Lectins/genetics
KW - Metabolism, Inborn Errors/complications
KW - Polymorphism, Genetic
U2 - 10.1371/journal.pone.0178032
DO - 10.1371/journal.pone.0178032
M3 - SCORING: Journal article
C2 - 28558032
VL - 12
SP - e0178032
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 5
ER -