The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.
Standard
The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. / Heise, Kirstin-Friederike; Zimerman, Maximo; Hoppe, Julia; Gerloff, Christian; Wegscheider, Karl; Hummel, Friedhelm C.
In: J NEUROSCI, Vol. 33, No. 21, 21, 2013, p. 9039-9049.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.
AU - Heise, Kirstin-Friederike
AU - Zimerman, Maximo
AU - Hoppe, Julia
AU - Gerloff, Christian
AU - Wegscheider, Karl
AU - Hummel, Friedhelm C
PY - 2013
Y1 - 2013
N2 - Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.
AB - Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Analysis of Variance
KW - Electromyography
KW - Evoked Potentials, Motor
KW - Female
KW - Functional Laterality
KW - Hand
KW - Humans
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Motor Cortex
KW - Neural Inhibition
KW - Neuronal Plasticity
KW - Reaction Time
KW - Rest
KW - Sex Factors
KW - Time Factors
KW - Transcranial Magnetic Stimulation
KW - Young Adult
U2 - 10.1523/JNEUROSCI.4094-12.2013
DO - 10.1523/JNEUROSCI.4094-12.2013
M3 - SCORING: Journal article
C2 - 23699515
VL - 33
SP - 9039
EP - 9049
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 21
M1 - 21
ER -