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The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.

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The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. / Heise, Kirstin-Friederike; Zimerman, Maximo; Hoppe, Julia; Gerloff, Christian; Wegscheider, Karl; Hummel, Friedhelm C.

in: J NEUROSCI, Jahrgang 33, Nr. 21, 21, 2013, S. 9039-9049.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heise, K-F, Zimerman, M, Hoppe, J, Gerloff, C, Wegscheider, K & Hummel, FC 2013, 'The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.', J NEUROSCI, Jg. 33, Nr. 21, 21, S. 9039-9049. https://doi.org/10.1523/JNEUROSCI.4094-12.2013

APA

Heise, K-F., Zimerman, M., Hoppe, J., Gerloff, C., Wegscheider, K., & Hummel, F. C. (2013). The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J NEUROSCI, 33(21), 9039-9049. [21]. https://doi.org/10.1523/JNEUROSCI.4094-12.2013

Vancouver

Heise K-F, Zimerman M, Hoppe J, Gerloff C, Wegscheider K, Hummel FC. The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J NEUROSCI. 2013;33(21):9039-9049. 21. https://doi.org/10.1523/JNEUROSCI.4094-12.2013

Bibtex

@article{cdb3180b38ee48a7a21805b78cc8b71f,
title = "The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.",
abstract = "Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.",
keywords = "Adult, Aged, Aged, 80 and over, Aging, Analysis of Variance, Electromyography, Evoked Potentials, Motor, Female, Functional Laterality, Hand, Humans, Linear Models, Male, Middle Aged, Motor Cortex, Neural Inhibition, Neuronal Plasticity, Reaction Time, Rest, Sex Factors, Time Factors, Transcranial Magnetic Stimulation, Young Adult",
author = "Kirstin-Friederike Heise and Maximo Zimerman and Julia Hoppe and Christian Gerloff and Karl Wegscheider and Hummel, {Friedhelm C}",
year = "2013",
doi = "10.1523/JNEUROSCI.4094-12.2013",
language = "English",
volume = "33",
pages = "9039--9049",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "21",

}

RIS

TY - JOUR

T1 - The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.

AU - Heise, Kirstin-Friederike

AU - Zimerman, Maximo

AU - Hoppe, Julia

AU - Gerloff, Christian

AU - Wegscheider, Karl

AU - Hummel, Friedhelm C

PY - 2013

Y1 - 2013

N2 - Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.

AB - Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Analysis of Variance

KW - Electromyography

KW - Evoked Potentials, Motor

KW - Female

KW - Functional Laterality

KW - Hand

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Motor Cortex

KW - Neural Inhibition

KW - Neuronal Plasticity

KW - Reaction Time

KW - Rest

KW - Sex Factors

KW - Time Factors

KW - Transcranial Magnetic Stimulation

KW - Young Adult

U2 - 10.1523/JNEUROSCI.4094-12.2013

DO - 10.1523/JNEUROSCI.4094-12.2013

M3 - SCORING: Journal article

C2 - 23699515

VL - 33

SP - 9039

EP - 9049

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 21

M1 - 21

ER -