TGF-beta and CD4+CD25+ regulatory T cells
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TGF-beta and CD4+CD25+ regulatory T cells. / Huber, Samuel; Schramm, Christoph.
In: FRONT BIOSCI-LANDMRK, Vol. 11, No. 1, 01.01.2006, p. 1014-1023.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - TGF-beta and CD4+CD25+ regulatory T cells
AU - Huber, Samuel
AU - Schramm, Christoph
PY - 2006/1/1
Y1 - 2006/1/1
N2 - TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.
AB - TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.
KW - Animals
KW - CD4 Antigens/metabolism
KW - CD4-Positive T-Lymphocytes/metabolism
KW - Cell Proliferation
KW - Cytokines/metabolism
KW - Gene Expression Regulation
KW - Humans
KW - Immune System/pathology
KW - Immunosuppressive Agents/metabolism
KW - In Vitro Techniques
KW - Models, Biological
KW - Receptors, Interleukin-2/biosynthesis
KW - Signal Transduction
KW - T-Lymphocytes, Regulatory/metabolism
KW - Thymus Gland/metabolism
KW - Transforming Growth Factor beta/metabolism
U2 - 10.2741/1859
DO - 10.2741/1859
M3 - SCORING: Review article
C2 - 16146793
VL - 11
SP - 1014
EP - 1023
JO - FRONT BIOSCI-LANDMRK
JF - FRONT BIOSCI-LANDMRK
SN - 2768-6701
IS - 1
ER -