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TGF-beta and CD4+CD25+ regulatory T cells

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TGF-beta and CD4+CD25+ regulatory T cells. / Huber, Samuel; Schramm, Christoph.

in: FRONT BIOSCI-LANDMRK, Jahrgang 11, Nr. 1, 01.01.2006, S. 1014-1023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Huber, S & Schramm, C 2006, 'TGF-beta and CD4+CD25+ regulatory T cells', FRONT BIOSCI-LANDMRK, Jg. 11, Nr. 1, S. 1014-1023. https://doi.org/10.2741/1859

APA

Huber, S., & Schramm, C. (2006). TGF-beta and CD4+CD25+ regulatory T cells. FRONT BIOSCI-LANDMRK, 11(1), 1014-1023. https://doi.org/10.2741/1859

Vancouver

Huber S, Schramm C. TGF-beta and CD4+CD25+ regulatory T cells. FRONT BIOSCI-LANDMRK. 2006 Jan 1;11(1):1014-1023. https://doi.org/10.2741/1859

Bibtex

@article{c655bdb250a94101a14ffe8fa09653a4,
title = "TGF-beta and CD4+CD25+ regulatory T cells",
abstract = "TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.",
keywords = "Animals, CD4 Antigens/metabolism, CD4-Positive T-Lymphocytes/metabolism, Cell Proliferation, Cytokines/metabolism, Gene Expression Regulation, Humans, Immune System/pathology, Immunosuppressive Agents/metabolism, In Vitro Techniques, Models, Biological, Receptors, Interleukin-2/biosynthesis, Signal Transduction, T-Lymphocytes, Regulatory/metabolism, Thymus Gland/metabolism, Transforming Growth Factor beta/metabolism",
author = "Samuel Huber and Christoph Schramm",
year = "2006",
month = jan,
day = "1",
doi = "10.2741/1859",
language = "English",
volume = "11",
pages = "1014--1023",
journal = "FRONT BIOSCI-LANDMRK",
issn = "2768-6701",
publisher = "Frontiers in Bioscience",
number = "1",

}

RIS

TY - JOUR

T1 - TGF-beta and CD4+CD25+ regulatory T cells

AU - Huber, Samuel

AU - Schramm, Christoph

PY - 2006/1/1

Y1 - 2006/1/1

N2 - TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.

AB - TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.

KW - Animals

KW - CD4 Antigens/metabolism

KW - CD4-Positive T-Lymphocytes/metabolism

KW - Cell Proliferation

KW - Cytokines/metabolism

KW - Gene Expression Regulation

KW - Humans

KW - Immune System/pathology

KW - Immunosuppressive Agents/metabolism

KW - In Vitro Techniques

KW - Models, Biological

KW - Receptors, Interleukin-2/biosynthesis

KW - Signal Transduction

KW - T-Lymphocytes, Regulatory/metabolism

KW - Thymus Gland/metabolism

KW - Transforming Growth Factor beta/metabolism

U2 - 10.2741/1859

DO - 10.2741/1859

M3 - SCORING: Review article

C2 - 16146793

VL - 11

SP - 1014

EP - 1023

JO - FRONT BIOSCI-LANDMRK

JF - FRONT BIOSCI-LANDMRK

SN - 2768-6701

IS - 1

ER -