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Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10

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Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. / Stolt, C Claus; Rehberg, Stephan; Ader, Marius; Lommes, Petra; Riethmacher, Dieter; Schachner, Melitta; Bartsch, Udo; Wegner, Michael.

In: GENE DEV, Vol. 16, No. 2, 15.01.2002, p. 165-70.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stolt, CC, Rehberg, S, Ader, M, Lommes, P, Riethmacher, D, Schachner, M, Bartsch, U & Wegner, M 2002, 'Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10', GENE DEV, vol. 16, no. 2, pp. 165-70. https://doi.org/10.1101/gad.215802

APA

Stolt, C. C., Rehberg, S., Ader, M., Lommes, P., Riethmacher, D., Schachner, M., Bartsch, U., & Wegner, M. (2002). Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. GENE DEV, 16(2), 165-70. https://doi.org/10.1101/gad.215802

Vancouver

Stolt CC, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M et al. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. GENE DEV. 2002 Jan 15;16(2):165-70. https://doi.org/10.1101/gad.215802

Bibtex

@article{9dfe73f6787e4d1396a2105c5a43cf98,
title = "Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10",
abstract = "Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.",
keywords = "Animals, Cell Differentiation, DNA-Binding Proteins, Genotype, High Mobility Group Proteins, Mice, Mice, Inbred C57BL, Mutation, Oligodendroglia, SOXE Transcription Factors, Transcription Factors, Journal Article, Research Support, Non-U.S. Gov't",
author = "Stolt, {C Claus} and Stephan Rehberg and Marius Ader and Petra Lommes and Dieter Riethmacher and Melitta Schachner and Udo Bartsch and Michael Wegner",
year = "2002",
month = jan,
day = "15",
doi = "10.1101/gad.215802",
language = "English",
volume = "16",
pages = "165--70",
journal = "GENE DEV",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "2",

}

RIS

TY - JOUR

T1 - Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10

AU - Stolt, C Claus

AU - Rehberg, Stephan

AU - Ader, Marius

AU - Lommes, Petra

AU - Riethmacher, Dieter

AU - Schachner, Melitta

AU - Bartsch, Udo

AU - Wegner, Michael

PY - 2002/1/15

Y1 - 2002/1/15

N2 - Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

AB - Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

KW - Animals

KW - Cell Differentiation

KW - DNA-Binding Proteins

KW - Genotype

KW - High Mobility Group Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Mutation

KW - Oligodendroglia

KW - SOXE Transcription Factors

KW - Transcription Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1101/gad.215802

DO - 10.1101/gad.215802

M3 - SCORING: Journal article

C2 - 11799060

VL - 16

SP - 165

EP - 170

JO - GENE DEV

JF - GENE DEV

SN - 0890-9369

IS - 2

ER -