Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
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Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. / Stolt, C Claus; Rehberg, Stephan; Ader, Marius; Lommes, Petra; Riethmacher, Dieter; Schachner, Melitta; Bartsch, Udo; Wegner, Michael.
in: GENE DEV, Jahrgang 16, Nr. 2, 15.01.2002, S. 165-70.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
AU - Stolt, C Claus
AU - Rehberg, Stephan
AU - Ader, Marius
AU - Lommes, Petra
AU - Riethmacher, Dieter
AU - Schachner, Melitta
AU - Bartsch, Udo
AU - Wegner, Michael
PY - 2002/1/15
Y1 - 2002/1/15
N2 - Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
AB - Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
KW - Animals
KW - Cell Differentiation
KW - DNA-Binding Proteins
KW - Genotype
KW - High Mobility Group Proteins
KW - Mice
KW - Mice, Inbred C57BL
KW - Mutation
KW - Oligodendroglia
KW - SOXE Transcription Factors
KW - Transcription Factors
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1101/gad.215802
DO - 10.1101/gad.215802
M3 - SCORING: Journal article
C2 - 11799060
VL - 16
SP - 165
EP - 170
JO - GENE DEV
JF - GENE DEV
SN - 0890-9369
IS - 2
ER -