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Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex

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Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex. / Vecchia, Dania; Beltramo, Riccardo; Vallone, Fabio; Chéreau, Ronan; Forli, Angelo; Molano-Mazón, Manuel; Bawa, Tanika; Binini, Noemi; Moretti, Claudio; Holtmaat, Anthony; Panzeri, Stefano; Fellin, Tommaso.

In: CURR BIOL, Vol. 30, No. 9, 04.05.2020, p. 1589-1599.e10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vecchia, D, Beltramo, R, Vallone, F, Chéreau, R, Forli, A, Molano-Mazón, M, Bawa, T, Binini, N, Moretti, C, Holtmaat, A, Panzeri, S & Fellin, T 2020, 'Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex', CURR BIOL, vol. 30, no. 9, pp. 1589-1599.e10. https://doi.org/10.1016/j.cub.2020.02.004

APA

Vecchia, D., Beltramo, R., Vallone, F., Chéreau, R., Forli, A., Molano-Mazón, M., Bawa, T., Binini, N., Moretti, C., Holtmaat, A., Panzeri, S., & Fellin, T. (2020). Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex. CURR BIOL, 30(9), 1589-1599.e10. https://doi.org/10.1016/j.cub.2020.02.004

Vancouver

Vecchia D, Beltramo R, Vallone F, Chéreau R, Forli A, Molano-Mazón M et al. Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex. CURR BIOL. 2020 May 4;30(9):1589-1599.e10. https://doi.org/10.1016/j.cub.2020.02.004

Bibtex

@article{65fb2ece663f483da418f7b40fafc7fe,
title = "Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex",
abstract = "The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.",
keywords = "Action Potentials/physiology, Animals, Mice, Neurons/physiology, Somatosensory Cortex/anatomy & histology, Time Factors, Touch/physiology, Touch Perception/physiology, Vibrissae/physiology",
author = "Dania Vecchia and Riccardo Beltramo and Fabio Vallone and Ronan Ch{\'e}reau and Angelo Forli and Manuel Molano-Maz{\'o}n and Tanika Bawa and Noemi Binini and Claudio Moretti and Anthony Holtmaat and Stefano Panzeri and Tommaso Fellin",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = may,
day = "4",
doi = "10.1016/j.cub.2020.02.004",
language = "English",
volume = "30",
pages = "1589--1599.e10",
journal = "CURR BIOL",
issn = "0960-9822",
publisher = "Cell Press",
number = "9",

}

RIS

TY - JOUR

T1 - Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex

AU - Vecchia, Dania

AU - Beltramo, Riccardo

AU - Vallone, Fabio

AU - Chéreau, Ronan

AU - Forli, Angelo

AU - Molano-Mazón, Manuel

AU - Bawa, Tanika

AU - Binini, Noemi

AU - Moretti, Claudio

AU - Holtmaat, Anthony

AU - Panzeri, Stefano

AU - Fellin, Tommaso

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/5/4

Y1 - 2020/5/4

N2 - The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.

AB - The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.

KW - Action Potentials/physiology

KW - Animals

KW - Mice

KW - Neurons/physiology

KW - Somatosensory Cortex/anatomy & histology

KW - Time Factors

KW - Touch/physiology

KW - Touch Perception/physiology

KW - Vibrissae/physiology

U2 - 10.1016/j.cub.2020.02.004

DO - 10.1016/j.cub.2020.02.004

M3 - SCORING: Journal article

C2 - 32169206

VL - 30

SP - 1589-1599.e10

JO - CURR BIOL

JF - CURR BIOL

SN - 0960-9822

IS - 9

ER -