Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex
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Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex. / Vecchia, Dania; Beltramo, Riccardo; Vallone, Fabio; Chéreau, Ronan; Forli, Angelo; Molano-Mazón, Manuel; Bawa, Tanika; Binini, Noemi; Moretti, Claudio; Holtmaat, Anthony; Panzeri, Stefano; Fellin, Tommaso.
in: CURR BIOL, Jahrgang 30, Nr. 9, 04.05.2020, S. 1589-1599.e10.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex
AU - Vecchia, Dania
AU - Beltramo, Riccardo
AU - Vallone, Fabio
AU - Chéreau, Ronan
AU - Forli, Angelo
AU - Molano-Mazón, Manuel
AU - Bawa, Tanika
AU - Binini, Noemi
AU - Moretti, Claudio
AU - Holtmaat, Anthony
AU - Panzeri, Stefano
AU - Fellin, Tommaso
N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2020/5/4
Y1 - 2020/5/4
N2 - The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
AB - The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
KW - Action Potentials/physiology
KW - Animals
KW - Mice
KW - Neurons/physiology
KW - Somatosensory Cortex/anatomy & histology
KW - Time Factors
KW - Touch/physiology
KW - Touch Perception/physiology
KW - Vibrissae/physiology
U2 - 10.1016/j.cub.2020.02.004
DO - 10.1016/j.cub.2020.02.004
M3 - SCORING: Journal article
C2 - 32169206
VL - 30
SP - 1589-1599.e10
JO - CURR BIOL
JF - CURR BIOL
SN - 0960-9822
IS - 9
ER -