Temporal control of immediate early gene induction by light.

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Abstract

The light-gated cation channel channelrhodopsin-2 (ChR2) is a powerful tool for the optical induction of action potentials in neurons. Mutations of the cysteine 128 (C128) residue have been shown to greatly extend the lifetime of the conducting state of ChR2. However, until now, only subthreshold depolarizations have been reported from C128 mutants.

Bibliographical data

Original languageEnglish
Article number12
ISSN1932-6203
Publication statusPublished - 2009
pubmed 19997631