Targeting transcription factor lysine acetylation in inflammatory airway diseases
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Targeting transcription factor lysine acetylation in inflammatory airway diseases. / van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J.
In: EPIGENOMICS-UK, Vol. 9, No. 7, 07.2017, p. 1013-1028.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Targeting transcription factor lysine acetylation in inflammatory airway diseases
AU - van den Bosch, Thea
AU - Kwiatkowski, Marcel
AU - Bischoff, Rainer
AU - Dekker, Frank J
PY - 2017/7
Y1 - 2017/7
N2 - Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.
AB - Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.
KW - Animals
KW - Asthma
KW - Histone Code
KW - Histone Deacetylase Inhibitors
KW - Humans
KW - Pulmonary Disease, Chronic Obstructive
KW - Transcription Factors
KW - Journal Article
KW - Review
U2 - 10.2217/epi-2017-0027
DO - 10.2217/epi-2017-0027
M3 - SCORING: Review article
C2 - 28617138
VL - 9
SP - 1013
EP - 1028
JO - EPIGENOMICS-UK
JF - EPIGENOMICS-UK
SN - 1750-1911
IS - 7
ER -