PortalPublikationenTargeting transcription factor lysine acetylation in inflamm...

Targeting transcription factor lysine acetylation in inflammatory airway diseases

Standard

Targeting transcription factor lysine acetylation in inflammatory airway diseases. / van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J.

in: EPIGENOMICS-UK, Jahrgang 9, Nr. 7, 07.2017, S. 1013-1028.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

van den Bosch, T, Kwiatkowski, M, Bischoff, R & Dekker, FJ 2017, 'Targeting transcription factor lysine acetylation in inflammatory airway diseases', EPIGENOMICS-UK, Jg. 9, Nr. 7, S. 1013-1028. https://doi.org/10.2217/epi-2017-0027

APA

van den Bosch, T., Kwiatkowski, M., Bischoff, R., & Dekker, F. J. (2017). Targeting transcription factor lysine acetylation in inflammatory airway diseases. EPIGENOMICS-UK, 9(7), 1013-1028. https://doi.org/10.2217/epi-2017-0027

Vancouver

van den Bosch T, Kwiatkowski M, Bischoff R, Dekker FJ. Targeting transcription factor lysine acetylation in inflammatory airway diseases. EPIGENOMICS-UK. 2017 Jul;9(7):1013-1028. https://doi.org/10.2217/epi-2017-0027

Bibtex

@article{b4505cf0c4a848428fbe476f40102ece,
title = "Targeting transcription factor lysine acetylation in inflammatory airway diseases",
abstract = "Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.",
keywords = "Animals, Asthma, Histone Code, Histone Deacetylase Inhibitors, Humans, Pulmonary Disease, Chronic Obstructive, Transcription Factors, Journal Article, Review",
author = "{van den Bosch}, Thea and Marcel Kwiatkowski and Rainer Bischoff and Dekker, {Frank J}",
year = "2017",
month = jul,
doi = "10.2217/epi-2017-0027",
language = "English",
volume = "9",
pages = "1013--1028",
journal = "EPIGENOMICS-UK",
issn = "1750-1911",
publisher = "Future Medicine Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Targeting transcription factor lysine acetylation in inflammatory airway diseases

AU - van den Bosch, Thea

AU - Kwiatkowski, Marcel

AU - Bischoff, Rainer

AU - Dekker, Frank J

PY - 2017/7

Y1 - 2017/7

N2 - Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.

AB - Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.

KW - Animals

KW - Asthma

KW - Histone Code

KW - Histone Deacetylase Inhibitors

KW - Humans

KW - Pulmonary Disease, Chronic Obstructive

KW - Transcription Factors

KW - Journal Article

KW - Review

U2 - 10.2217/epi-2017-0027

DO - 10.2217/epi-2017-0027

M3 - SCORING: Review article

C2 - 28617138

VL - 9

SP - 1013

EP - 1028

JO - EPIGENOMICS-UK

JF - EPIGENOMICS-UK

SN - 1750-1911

IS - 7

ER -