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Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.

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Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model. / Fraedrich, Katharina; Schrader, Jörg; Ittrich, Harald; von Amsberg, Gunhild; Gontarewicz, Artur; Matzat, Verena; Kromminga, Arno; Pace, Andrea; Moll, Jürgen; Bläker, Michael; Lohse, Ansgar W.; Hörsch, Dieter; Brümmendorf, Tim; Benten, Daniel.

In: CLIN CANCER RES, Vol. 18, No. 17, 17, 2012, p. 4621-4632.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fraedrich, K, Schrader, J, Ittrich, H, von Amsberg, G, Gontarewicz, A, Matzat, V, Kromminga, A, Pace, A, Moll, J, Bläker, M, Lohse, AW, Hörsch, D, Brümmendorf, T & Benten, D 2012, 'Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.', CLIN CANCER RES, vol. 18, no. 17, 17, pp. 4621-4632. <http://www.ncbi.nlm.nih.gov/pubmed/22753592?dopt=Citation>

APA

Fraedrich, K., Schrader, J., Ittrich, H., von Amsberg, G., Gontarewicz, A., Matzat, V., Kromminga, A., Pace, A., Moll, J., Bläker, M., Lohse, A. W., Hörsch, D., Brümmendorf, T., & Benten, D. (2012). Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model. CLIN CANCER RES, 18(17), 4621-4632. [17]. http://www.ncbi.nlm.nih.gov/pubmed/22753592?dopt=Citation

Vancouver

Fraedrich K, Schrader J, Ittrich H, von Amsberg G, Gontarewicz A, Matzat V et al. Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model. CLIN CANCER RES. 2012;18(17):4621-4632. 17.

Bibtex

@article{683ff5a2fbf34702ae85a5e2ffe539ca,
title = "Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.",
abstract = "Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies.",
keywords = "Animals, Humans, Mice, Cell Line, Tumor, Cell Proliferation/drug effects, Molecular Targeted Therapy, Transplantation, Heterologous, Cell Cycle Checkpoints/drug effects, Histones/metabolism, Benzamides/*administration & dosage, Chromogranin A/blood, *Gastrointestinal Neoplasms/drug therapy/metabolism/pathology, Liver Neoplasms/*drug therapy/pathology/secondary, Neuroendocrine Tumors/drug therapy/metabolism/pathology, *Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Pyrazoles/*administration & dosage, Animals, Humans, Mice, Cell Line, Tumor, Cell Proliferation/drug effects, Molecular Targeted Therapy, Transplantation, Heterologous, Cell Cycle Checkpoints/drug effects, Histones/metabolism, Benzamides/*administration & dosage, Chromogranin A/blood, *Gastrointestinal Neoplasms/drug therapy/metabolism/pathology, Liver Neoplasms/*drug therapy/pathology/secondary, Neuroendocrine Tumors/drug therapy/metabolism/pathology, *Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Pyrazoles/*administration & dosage",
author = "Katharina Fraedrich and J{\"o}rg Schrader and Harald Ittrich and {von Amsberg}, Gunhild and Artur Gontarewicz and Verena Matzat and Arno Kromminga and Andrea Pace and J{\"u}rgen Moll and Michael Bl{\"a}ker and Lohse, {Ansgar W.} and Dieter H{\"o}rsch and Tim Br{\"u}mmendorf and Daniel Benten",
year = "2012",
language = "English",
volume = "18",
pages = "4621--4632",
journal = "CLIN CANCER RES",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "17",

}

RIS

TY - JOUR

T1 - Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.

AU - Fraedrich, Katharina

AU - Schrader, Jörg

AU - Ittrich, Harald

AU - von Amsberg, Gunhild

AU - Gontarewicz, Artur

AU - Matzat, Verena

AU - Kromminga, Arno

AU - Pace, Andrea

AU - Moll, Jürgen

AU - Bläker, Michael

AU - Lohse, Ansgar W.

AU - Hörsch, Dieter

AU - Brümmendorf, Tim

AU - Benten, Daniel

PY - 2012

Y1 - 2012

N2 - Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies.

AB - Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies.

KW - Animals

KW - Humans

KW - Mice

KW - Cell Line, Tumor

KW - Cell Proliferation/drug effects

KW - Molecular Targeted Therapy

KW - Transplantation, Heterologous

KW - Cell Cycle Checkpoints/drug effects

KW - Histones/metabolism

KW - Benzamides/administration & dosage

KW - Chromogranin A/blood

KW - Gastrointestinal Neoplasms/drug therapy/metabolism/pathology

KW - Liver Neoplasms/drug therapy/pathology/secondary

KW - Neuroendocrine Tumors/drug therapy/metabolism/pathology

KW - Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism

KW - Pyrazoles/administration & dosage

KW - Animals

KW - Humans

KW - Mice

KW - Cell Line, Tumor

KW - Cell Proliferation/drug effects

KW - Molecular Targeted Therapy

KW - Transplantation, Heterologous

KW - Cell Cycle Checkpoints/drug effects

KW - Histones/metabolism

KW - Benzamides/administration & dosage

KW - Chromogranin A/blood

KW - Gastrointestinal Neoplasms/drug therapy/metabolism/pathology

KW - Liver Neoplasms/drug therapy/pathology/secondary

KW - Neuroendocrine Tumors/drug therapy/metabolism/pathology

KW - Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism

KW - Pyrazoles/administration & dosage

M3 - SCORING: Journal article

VL - 18

SP - 4621

EP - 4632

JO - CLIN CANCER RES

JF - CLIN CANCER RES

SN - 1078-0432

IS - 17

M1 - 17

ER -