Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.
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Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model. / Fraedrich, Katharina; Schrader, Jörg; Ittrich, Harald; von Amsberg, Gunhild; Gontarewicz, Artur; Matzat, Verena; Kromminga, Arno; Pace, Andrea; Moll, Jürgen; Bläker, Michael; Lohse, Ansgar W.; Hörsch, Dieter; Brümmendorf, Tim; Benten, Daniel.
in: CLIN CANCER RES, Jahrgang 18, Nr. 17, 17, 2012, S. 4621-4632.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.
AU - Fraedrich, Katharina
AU - Schrader, Jörg
AU - Ittrich, Harald
AU - von Amsberg, Gunhild
AU - Gontarewicz, Artur
AU - Matzat, Verena
AU - Kromminga, Arno
AU - Pace, Andrea
AU - Moll, Jürgen
AU - Bläker, Michael
AU - Lohse, Ansgar W.
AU - Hörsch, Dieter
AU - Brümmendorf, Tim
AU - Benten, Daniel
PY - 2012
Y1 - 2012
N2 - Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies.
AB - Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies.
KW - Animals
KW - Humans
KW - Mice
KW - Cell Line, Tumor
KW - Cell Proliferation/drug effects
KW - Molecular Targeted Therapy
KW - Transplantation, Heterologous
KW - Cell Cycle Checkpoints/drug effects
KW - Histones/metabolism
KW - Benzamides/administration & dosage
KW - Chromogranin A/blood
KW - Gastrointestinal Neoplasms/drug therapy/metabolism/pathology
KW - Liver Neoplasms/drug therapy/pathology/secondary
KW - Neuroendocrine Tumors/drug therapy/metabolism/pathology
KW - Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism
KW - Pyrazoles/administration & dosage
KW - Animals
KW - Humans
KW - Mice
KW - Cell Line, Tumor
KW - Cell Proliferation/drug effects
KW - Molecular Targeted Therapy
KW - Transplantation, Heterologous
KW - Cell Cycle Checkpoints/drug effects
KW - Histones/metabolism
KW - Benzamides/administration & dosage
KW - Chromogranin A/blood
KW - Gastrointestinal Neoplasms/drug therapy/metabolism/pathology
KW - Liver Neoplasms/drug therapy/pathology/secondary
KW - Neuroendocrine Tumors/drug therapy/metabolism/pathology
KW - Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism
KW - Pyrazoles/administration & dosage
M3 - SCORING: Journal article
VL - 18
SP - 4621
EP - 4632
JO - CLIN CANCER RES
JF - CLIN CANCER RES
SN - 1078-0432
IS - 17
M1 - 17
ER -