TAM Receptor Signaling in Immune Homeostasis
Standard
TAM Receptor Signaling in Immune Homeostasis. / Rothlin, C.V.; Carrera-Silva, E.A.; Bosurgi, L.; Ghosh, S.
In: ANNU REV IMMUNOL, Vol. 33, 2015, p. 355–391.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - TAM Receptor Signaling in Immune Homeostasis
AU - Rothlin, C.V.
AU - Carrera-Silva, E.A.
AU - Bosurgi, L.
AU - Ghosh, S.
PY - 2015
Y1 - 2015
N2 - The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
AB - The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84927593061&partnerID=MN8TOARS
U2 - 10.1146/annurev-immunol-032414-112103
DO - 10.1146/annurev-immunol-032414-112103
M3 - SCORING: Review article
C2 - 25594431
VL - 33
SP - 355
EP - 391
JO - ANNU REV IMMUNOL
JF - ANNU REV IMMUNOL
SN - 0732-0582
ER -