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TAM Receptor Signaling in Immune Homeostasis

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TAM Receptor Signaling in Immune Homeostasis. / Rothlin, C.V.; Carrera-Silva, E.A.; Bosurgi, L.; Ghosh, S.

in: ANNU REV IMMUNOL, Jahrgang 33, 2015, S. 355–391.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Rothlin, CV, Carrera-Silva, EA, Bosurgi, L & Ghosh, S 2015, 'TAM Receptor Signaling in Immune Homeostasis', ANNU REV IMMUNOL, Jg. 33, S. 355–391. https://doi.org/10.1146/annurev-immunol-032414-112103

APA

Rothlin, C. V., Carrera-Silva, E. A., Bosurgi, L., & Ghosh, S. (2015). TAM Receptor Signaling in Immune Homeostasis. ANNU REV IMMUNOL, 33, 355–391. https://doi.org/10.1146/annurev-immunol-032414-112103

Vancouver

Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM Receptor Signaling in Immune Homeostasis. ANNU REV IMMUNOL. 2015;33:355–391. https://doi.org/10.1146/annurev-immunol-032414-112103

Bibtex

@article{888f41137c004fe293a47d218ae977f0,
title = "TAM Receptor Signaling in Immune Homeostasis",
abstract = "The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.",
author = "C.V. Rothlin and E.A. Carrera-Silva and L. Bosurgi and S. Ghosh",
year = "2015",
doi = "10.1146/annurev-immunol-032414-112103",
language = "English",
volume = "33",
pages = "355–391",
journal = "ANNU REV IMMUNOL",
issn = "0732-0582",
publisher = "Annual Reviews Inc.",

}

RIS

TY - JOUR

T1 - TAM Receptor Signaling in Immune Homeostasis

AU - Rothlin, C.V.

AU - Carrera-Silva, E.A.

AU - Bosurgi, L.

AU - Ghosh, S.

PY - 2015

Y1 - 2015

N2 - The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.

AB - The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84927593061&partnerID=MN8TOARS

U2 - 10.1146/annurev-immunol-032414-112103

DO - 10.1146/annurev-immunol-032414-112103

M3 - SCORING: Review article

C2 - 25594431

VL - 33

SP - 355

EP - 391

JO - ANNU REV IMMUNOL

JF - ANNU REV IMMUNOL

SN - 0732-0582

ER -