Systems Medicine as an Emerging Tool for Cardiovascular Genetics
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Systems Medicine as an Emerging Tool for Cardiovascular Genetics. / Haase, Tina; Börnigen, Daniela; Müller, Christian; Zeller, Tanja.
In: FRONT CARDIOVASC MED, Vol. 3, 2016, p. 27.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Systems Medicine as an Emerging Tool for Cardiovascular Genetics
AU - Haase, Tina
AU - Börnigen, Daniela
AU - Müller, Christian
AU - Zeller, Tanja
PY - 2016
Y1 - 2016
N2 - Cardiovascular disease (CVD) is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of CVD is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular, and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in CVD. They include bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses. Additionally, we discuss challenges and current literature examples where systems medicine has been successfully applied for the study of CVD.
AB - Cardiovascular disease (CVD) is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of CVD is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular, and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in CVD. They include bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses. Additionally, we discuss challenges and current literature examples where systems medicine has been successfully applied for the study of CVD.
KW - Journal Article
KW - Review
U2 - 10.3389/fcvm.2016.00027
DO - 10.3389/fcvm.2016.00027
M3 - SCORING: Review article
C2 - 27626034
VL - 3
SP - 27
JO - FRONT CARDIOVASC MED
JF - FRONT CARDIOVASC MED
SN - 2297-055X
ER -