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Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia

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Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia. / Richards, Sue; Pui, Ching-Hon; Gayon, Paul; Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG).

In: PEDIATR BLOOD CANCER, Vol. 60, No. 2, 01.02.2013, p. 185-95.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Richards, S, Pui, C-H, Gayon, P & Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG) 2013, 'Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia', PEDIATR BLOOD CANCER, vol. 60, no. 2, pp. 185-95. https://doi.org/10.1002/pbc.24228

APA

Richards, S., Pui, C-H., Gayon, P., & Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG) (2013). Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia. PEDIATR BLOOD CANCER, 60(2), 185-95. https://doi.org/10.1002/pbc.24228

Vancouver

Richards S, Pui C-H, Gayon P, Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG). Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia. PEDIATR BLOOD CANCER. 2013 Feb 1;60(2):185-95. https://doi.org/10.1002/pbc.24228

Bibtex

@article{980dbe226f474972bc80d716684ce4b6,
title = "Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia",
abstract = "Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.",
keywords = "Antineoplastic Agents, Central Nervous System, Central Nervous System Neoplasms, Child, Humans, Injections, Spinal, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Randomized Controlled Trials as Topic",
author = "Sue Richards and Ching-Hon Pui and Paul Gayon and {Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)} and Gabriele Escherich",
note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",
year = "2013",
month = feb,
day = "1",
doi = "10.1002/pbc.24228",
language = "English",
volume = "60",
pages = "185--95",
journal = "PEDIATR BLOOD CANCER",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia

AU - Richards, Sue

AU - Pui, Ching-Hon

AU - Gayon, Paul

AU - Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)

AU - Escherich, Gabriele

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.

AB - Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.

KW - Antineoplastic Agents

KW - Central Nervous System

KW - Central Nervous System Neoplasms

KW - Child

KW - Humans

KW - Injections, Spinal

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Randomized Controlled Trials as Topic

U2 - 10.1002/pbc.24228

DO - 10.1002/pbc.24228

M3 - SCORING: Journal article

C2 - 22693038

VL - 60

SP - 185

EP - 195

JO - PEDIATR BLOOD CANCER

JF - PEDIATR BLOOD CANCER

SN - 1545-5009

IS - 2

ER -