Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia
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Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia. / Richards, Sue; Pui, Ching-Hon; Gayon, Paul; Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG).
in: PEDIATR BLOOD CANCER, Jahrgang 60, Nr. 2, 01.02.2013, S. 185-95.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia
AU - Richards, Sue
AU - Pui, Ching-Hon
AU - Gayon, Paul
AU - Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)
AU - Escherich, Gabriele
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.
AB - Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MTX improved both outcomes. One trial resulted in similar EFS and survival with IV MTX plus IT MTX versus TIT alone. Radiotherapy can generally be replaced by IT therapy. TIT should be used with effective systemic therapy such as IV MTX.
KW - Antineoplastic Agents
KW - Central Nervous System
KW - Central Nervous System Neoplasms
KW - Child
KW - Humans
KW - Injections, Spinal
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW - Randomized Controlled Trials as Topic
U2 - 10.1002/pbc.24228
DO - 10.1002/pbc.24228
M3 - SCORING: Journal article
C2 - 22693038
VL - 60
SP - 185
EP - 195
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 2
ER -