Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
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Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS). / Scheer, Monika; Blank, Bernd; Bauer, Sebastian; Vokuhl, Christian; Stegmaier, Sabine; Feuchtgruber, Simone; Henssen, Anton; Sparber-Sauer, Monika; Eggert, Angelika; Handgretinger, Ruppert; Pekrun, Arnulf; Rossig, Claudia; Rutkowski, Stefan; Schlegel, Paul-Gerhardt; Schrappe, Martin; Simon, Thorsten; Kazanowska, Bernarda; Niggli, Felix; Ladenstein, Ruth; Ljungman, Gustaf; Jahnukainen, Kirsi; Fuchs, Jörg; Bielack, Stefan S; Koscielniak, Ewa; Klingebiel, Thomas; Cooperative Weichteilsarkom Studiengruppe [CWS].
In: J CANCER RES CLIN, Vol. 146, No. 4, 04.2020, p. 953-960.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
AU - Scheer, Monika
AU - Blank, Bernd
AU - Bauer, Sebastian
AU - Vokuhl, Christian
AU - Stegmaier, Sabine
AU - Feuchtgruber, Simone
AU - Henssen, Anton
AU - Sparber-Sauer, Monika
AU - Eggert, Angelika
AU - Handgretinger, Ruppert
AU - Pekrun, Arnulf
AU - Rossig, Claudia
AU - Rutkowski, Stefan
AU - Schlegel, Paul-Gerhardt
AU - Schrappe, Martin
AU - Simon, Thorsten
AU - Kazanowska, Bernarda
AU - Niggli, Felix
AU - Ladenstein, Ruth
AU - Ljungman, Gustaf
AU - Jahnukainen, Kirsi
AU - Fuchs, Jörg
AU - Bielack, Stefan S
AU - Koscielniak, Ewa
AU - Klingebiel, Thomas
AU - Cooperative Weichteilsarkom Studiengruppe [CWS]
PY - 2020/4
Y1 - 2020/4
N2 - BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.DISCUSSION: The causes for these variations require further exploration.
AB - BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.DISCUSSION: The causes for these variations require further exploration.
KW - Adolescent
KW - Age of Onset
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Infant
KW - Male
KW - Neoplasm Invasiveness
KW - Neoplasm Metastasis
KW - Neoplasm Staging
KW - Sarcoma, Synovial/pathology
KW - Young Adult
U2 - 10.1007/s00432-019-03121-9
DO - 10.1007/s00432-019-03121-9
M3 - SCORING: Journal article
C2 - 31932909
VL - 146
SP - 953
EP - 960
JO - J CANCER RES CLIN
JF - J CANCER RES CLIN
SN - 0171-5216
IS - 4
ER -