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Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)

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Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS). / Scheer, Monika; Blank, Bernd; Bauer, Sebastian; Vokuhl, Christian; Stegmaier, Sabine; Feuchtgruber, Simone; Henssen, Anton; Sparber-Sauer, Monika; Eggert, Angelika; Handgretinger, Ruppert; Pekrun, Arnulf; Rossig, Claudia; Rutkowski, Stefan; Schlegel, Paul-Gerhardt; Schrappe, Martin; Simon, Thorsten; Kazanowska, Bernarda; Niggli, Felix; Ladenstein, Ruth; Ljungman, Gustaf; Jahnukainen, Kirsi; Fuchs, Jörg; Bielack, Stefan S; Koscielniak, Ewa; Klingebiel, Thomas; Cooperative Weichteilsarkom Studiengruppe [CWS].

in: J CANCER RES CLIN, Jahrgang 146, Nr. 4, 04.2020, S. 953-960.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Scheer, M, Blank, B, Bauer, S, Vokuhl, C, Stegmaier, S, Feuchtgruber, S, Henssen, A, Sparber-Sauer, M, Eggert, A, Handgretinger, R, Pekrun, A, Rossig, C, Rutkowski, S, Schlegel, P-G, Schrappe, M, Simon, T, Kazanowska, B, Niggli, F, Ladenstein, R, Ljungman, G, Jahnukainen, K, Fuchs, J, Bielack, SS, Koscielniak, E, Klingebiel, T & Cooperative Weichteilsarkom Studiengruppe [CWS] 2020, 'Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)', J CANCER RES CLIN, Jg. 146, Nr. 4, S. 953-960. https://doi.org/10.1007/s00432-019-03121-9

APA

Scheer, M., Blank, B., Bauer, S., Vokuhl, C., Stegmaier, S., Feuchtgruber, S., Henssen, A., Sparber-Sauer, M., Eggert, A., Handgretinger, R., Pekrun, A., Rossig, C., Rutkowski, S., Schlegel, P-G., Schrappe, M., Simon, T., Kazanowska, B., Niggli, F., Ladenstein, R., ... Cooperative Weichteilsarkom Studiengruppe [CWS] (2020). Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS). J CANCER RES CLIN, 146(4), 953-960. https://doi.org/10.1007/s00432-019-03121-9

Vancouver

Scheer M, Blank B, Bauer S, Vokuhl C, Stegmaier S, Feuchtgruber S et al. Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS). J CANCER RES CLIN. 2020 Apr;146(4):953-960. https://doi.org/10.1007/s00432-019-03121-9

Bibtex

@article{fb80bc32d3c149498031789114fc6b7b,
title = "Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)",
abstract = "BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.DISCUSSION: The causes for these variations require further exploration.",
keywords = "Adolescent, Age of Onset, Child, Child, Preschool, Female, Humans, Infant, Male, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Staging, Sarcoma, Synovial/pathology, Young Adult",
author = "Monika Scheer and Bernd Blank and Sebastian Bauer and Christian Vokuhl and Sabine Stegmaier and Simone Feuchtgruber and Anton Henssen and Monika Sparber-Sauer and Angelika Eggert and Ruppert Handgretinger and Arnulf Pekrun and Claudia Rossig and Stefan Rutkowski and Paul-Gerhardt Schlegel and Martin Schrappe and Thorsten Simon and Bernarda Kazanowska and Felix Niggli and Ruth Ladenstein and Gustaf Ljungman and Kirsi Jahnukainen and J{\"o}rg Fuchs and Bielack, {Stefan S} and Ewa Koscielniak and Thomas Klingebiel and {Cooperative Weichteilsarkom Studiengruppe [CWS]}",
year = "2020",
month = apr,
doi = "10.1007/s00432-019-03121-9",
language = "English",
volume = "146",
pages = "953--960",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)

AU - Scheer, Monika

AU - Blank, Bernd

AU - Bauer, Sebastian

AU - Vokuhl, Christian

AU - Stegmaier, Sabine

AU - Feuchtgruber, Simone

AU - Henssen, Anton

AU - Sparber-Sauer, Monika

AU - Eggert, Angelika

AU - Handgretinger, Ruppert

AU - Pekrun, Arnulf

AU - Rossig, Claudia

AU - Rutkowski, Stefan

AU - Schlegel, Paul-Gerhardt

AU - Schrappe, Martin

AU - Simon, Thorsten

AU - Kazanowska, Bernarda

AU - Niggli, Felix

AU - Ladenstein, Ruth

AU - Ljungman, Gustaf

AU - Jahnukainen, Kirsi

AU - Fuchs, Jörg

AU - Bielack, Stefan S

AU - Koscielniak, Ewa

AU - Klingebiel, Thomas

AU - Cooperative Weichteilsarkom Studiengruppe [CWS]

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.DISCUSSION: The causes for these variations require further exploration.

AB - BACKGROUND: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.METHODS: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.RESULTS: The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).CONCLUSIONS: The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.DISCUSSION: The causes for these variations require further exploration.

KW - Adolescent

KW - Age of Onset

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplasm Staging

KW - Sarcoma, Synovial/pathology

KW - Young Adult

U2 - 10.1007/s00432-019-03121-9

DO - 10.1007/s00432-019-03121-9

M3 - SCORING: Journal article

C2 - 31932909

VL - 146

SP - 953

EP - 960

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 4

ER -