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Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers

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Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. / Weiss, Peter H; Herzog, Jan; Pötter-Nerger, Monika; Falk, Daniela; Herzog, Hans; Deuschl, Günther; Volkmann, Jens; Fink, Gereon R.

In: MOVEMENT DISORD, Vol. 30, No. 8, 07.2015, p. 1121-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weiss, PH, Herzog, J, Pötter-Nerger, M, Falk, D, Herzog, H, Deuschl, G, Volkmann, J & Fink, GR 2015, 'Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers', MOVEMENT DISORD, vol. 30, no. 8, pp. 1121-5. https://doi.org/10.1002/mds.26229

APA

Weiss, P. H., Herzog, J., Pötter-Nerger, M., Falk, D., Herzog, H., Deuschl, G., Volkmann, J., & Fink, G. R. (2015). Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. MOVEMENT DISORD, 30(8), 1121-5. https://doi.org/10.1002/mds.26229

Vancouver

Weiss PH, Herzog J, Pötter-Nerger M, Falk D, Herzog H, Deuschl G et al. Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. MOVEMENT DISORD. 2015 Jul;30(8):1121-5. https://doi.org/10.1002/mds.26229

Bibtex

@article{b18e5b2c70034e0b9b3e4af8c92c6855,
title = "Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers",
abstract = "BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD.METHODS: Ten PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET.RESULTS: Independent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR).CONCLUSIONS: Data suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity.",
author = "Weiss, {Peter H} and Jan Herzog and Monika P{\"o}tter-Nerger and Daniela Falk and Hans Herzog and G{\"u}nther Deuschl and Jens Volkmann and Fink, {Gereon R}",
note = "{\textcopyright} 2015 International Parkinson and Movement Disorder Society.",
year = "2015",
month = jul,
doi = "10.1002/mds.26229",
language = "English",
volume = "30",
pages = "1121--5",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers

AU - Weiss, Peter H

AU - Herzog, Jan

AU - Pötter-Nerger, Monika

AU - Falk, Daniela

AU - Herzog, Hans

AU - Deuschl, Günther

AU - Volkmann, Jens

AU - Fink, Gereon R

N1 - © 2015 International Parkinson and Movement Disorder Society.

PY - 2015/7

Y1 - 2015/7

N2 - BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD.METHODS: Ten PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET.RESULTS: Independent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR).CONCLUSIONS: Data suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity.

AB - BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD.METHODS: Ten PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET.RESULTS: Independent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR).CONCLUSIONS: Data suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity.

U2 - 10.1002/mds.26229

DO - 10.1002/mds.26229

M3 - SCORING: Journal article

C2 - 25914247

VL - 30

SP - 1121

EP - 1125

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 8

ER -