Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers
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Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. / Weiss, Peter H; Herzog, Jan; Pötter-Nerger, Monika; Falk, Daniela; Herzog, Hans; Deuschl, Günther; Volkmann, Jens; Fink, Gereon R.
in: MOVEMENT DISORD, Jahrgang 30, Nr. 8, 07.2015, S. 1121-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers
AU - Weiss, Peter H
AU - Herzog, Jan
AU - Pötter-Nerger, Monika
AU - Falk, Daniela
AU - Herzog, Hans
AU - Deuschl, Günther
AU - Volkmann, Jens
AU - Fink, Gereon R
N1 - © 2015 International Parkinson and Movement Disorder Society.
PY - 2015/7
Y1 - 2015/7
N2 - BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD.METHODS: Ten PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET.RESULTS: Independent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR).CONCLUSIONS: Data suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity.
AB - BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD.METHODS: Ten PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET.RESULTS: Independent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR).CONCLUSIONS: Data suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity.
U2 - 10.1002/mds.26229
DO - 10.1002/mds.26229
M3 - SCORING: Journal article
C2 - 25914247
VL - 30
SP - 1121
EP - 1125
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 8
ER -