Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements.
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Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements. / Wenzelburger, Roland; Kopper, Florian; Zhang, Bao-Rong; Witt, Karsten; Hamel, Wolfgang; Weinert, Dieter; Kuhtz-Buschbeck, Johann; Gölge, Mukaddes; Illert, Michael; Deuschl, Günther; Krack, Paul.
In: MOVEMENT DISORD, Vol. 18, No. 10, 10, 2003, p. 1162-1169.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements.
AU - Wenzelburger, Roland
AU - Kopper, Florian
AU - Zhang, Bao-Rong
AU - Witt, Karsten
AU - Hamel, Wolfgang
AU - Weinert, Dieter
AU - Kuhtz-Buschbeck, Johann
AU - Gölge, Mukaddes
AU - Illert, Michael
AU - Deuschl, Günther
AU - Krack, Paul
PY - 2003
Y1 - 2003
N2 - Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L-dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS-items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L-dopa test than in the pure STN-DBS condition. Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions.
AB - Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L-dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS-items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L-dopa test than in the pure STN-DBS condition. Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions.
M3 - SCORING: Journal article
VL - 18
SP - 1162
EP - 1169
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 10
M1 - 10
ER -