Research ExplorerPublicationsStressful life events are associated with striatal dopamine ...

Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence

Standard

Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence. / Sebold, M; Spitta, G; Gleich, T; Dembler-Stamm, T; Butler, O; Zacharias, K; Aydin, S; Garbusow, M; Rapp, M; Schubert, F; Buchert, R; Gallinat, J; Heinz, A.

In: J NEURAL TRANSM, Vol. 126, No. 9, 09.2019, p. 1127-1134.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sebold, M, Spitta, G, Gleich, T, Dembler-Stamm, T, Butler, O, Zacharias, K, Aydin, S, Garbusow, M, Rapp, M, Schubert, F, Buchert, R, Gallinat, J & Heinz, A 2019, 'Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence', J NEURAL TRANSM, vol. 126, no. 9, pp. 1127-1134. https://doi.org/10.1007/s00702-019-01985-2

APA

Sebold, M., Spitta, G., Gleich, T., Dembler-Stamm, T., Butler, O., Zacharias, K., Aydin, S., Garbusow, M., Rapp, M., Schubert, F., Buchert, R., Gallinat, J., & Heinz, A. (2019). Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence. J NEURAL TRANSM, 126(9), 1127-1134. https://doi.org/10.1007/s00702-019-01985-2

Vancouver

Sebold M, Spitta G, Gleich T, Dembler-Stamm T, Butler O, Zacharias K et al. Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence. J NEURAL TRANSM. 2019 Sep;126(9):1127-1134. https://doi.org/10.1007/s00702-019-01985-2

Bibtex

@article{7cab768a57ae46f68466232639afb1a7,
title = "Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence",
abstract = "Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [18F]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction. CLINICAL TRIAL REGISTRATION: NCT01679145.",
keywords = "Journal Article",
author = "M Sebold and G Spitta and T Gleich and T Dembler-Stamm and O Butler and K Zacharias and S Aydin and M Garbusow and M Rapp and F Schubert and R Buchert and J Gallinat and A Heinz",
year = "2019",
month = sep,
doi = "10.1007/s00702-019-01985-2",
language = "English",
volume = "126",
pages = "1127--1134",
journal = "J NEURAL TRANSM",
issn = "0300-9564",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence

AU - Sebold, M

AU - Spitta, G

AU - Gleich, T

AU - Dembler-Stamm, T

AU - Butler, O

AU - Zacharias, K

AU - Aydin, S

AU - Garbusow, M

AU - Rapp, M

AU - Schubert, F

AU - Buchert, R

AU - Gallinat, J

AU - Heinz, A

PY - 2019/9

Y1 - 2019/9

N2 - Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [18F]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction. CLINICAL TRIAL REGISTRATION: NCT01679145.

AB - Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [18F]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction. CLINICAL TRIAL REGISTRATION: NCT01679145.

KW - Journal Article

U2 - 10.1007/s00702-019-01985-2

DO - 10.1007/s00702-019-01985-2

M3 - SCORING: Journal article

C2 - 30747311

VL - 126

SP - 1127

EP - 1134

JO - J NEURAL TRANSM

JF - J NEURAL TRANSM

SN - 0300-9564

IS - 9

ER -