Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence
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Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence. / Sebold, M; Spitta, G; Gleich, T; Dembler-Stamm, T; Butler, O; Zacharias, K; Aydin, S; Garbusow, M; Rapp, M; Schubert, F; Buchert, R; Gallinat, J; Heinz, A.
in: J NEURAL TRANSM, Jahrgang 126, Nr. 9, 09.2019, S. 1127-1134.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence
AU - Sebold, M
AU - Spitta, G
AU - Gleich, T
AU - Dembler-Stamm, T
AU - Butler, O
AU - Zacharias, K
AU - Aydin, S
AU - Garbusow, M
AU - Rapp, M
AU - Schubert, F
AU - Buchert, R
AU - Gallinat, J
AU - Heinz, A
PY - 2019/9
Y1 - 2019/9
N2 - Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [18F]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction. CLINICAL TRIAL REGISTRATION: NCT01679145.
AB - Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [18F]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction. CLINICAL TRIAL REGISTRATION: NCT01679145.
KW - Journal Article
U2 - 10.1007/s00702-019-01985-2
DO - 10.1007/s00702-019-01985-2
M3 - SCORING: Journal article
C2 - 30747311
VL - 126
SP - 1127
EP - 1134
JO - J NEURAL TRANSM
JF - J NEURAL TRANSM
SN - 0300-9564
IS - 9
ER -