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Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary

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Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary. / Dziggel, Liesa; Bajrovic, Amira; Schild, Steven E; Rades, Dirk.

In: ANTICANCER RES, Vol. 38, No. 1, 01.2018, p. 565-567.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dziggel, L, Bajrovic, A, Schild, SE & Rades, D 2018, 'Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary', ANTICANCER RES, vol. 38, no. 1, pp. 565-567. https://doi.org/10.21873/anticanres.12260

APA

Dziggel, L., Bajrovic, A., Schild, S. E., & Rades, D. (2018). Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary. ANTICANCER RES, 38(1), 565-567. https://doi.org/10.21873/anticanres.12260

Vancouver

Dziggel L, Bajrovic A, Schild SE, Rades D. Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary. ANTICANCER RES. 2018 Jan;38(1):565-567. https://doi.org/10.21873/anticanres.12260

Bibtex

@article{e78dd51fbc934fc9a59fdb3e17888e11,
title = "Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary",
abstract = "BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.RESULTS: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.CONCLUSION: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.",
keywords = "Brain Neoplasms, Cranial Irradiation, Female, Humans, Male, Middle Aged, Neoplasms, Unknown Primary, Radiosurgery, Survival Rate, Treatment Outcome, Journal Article",
author = "Liesa Dziggel and Amira Bajrovic and Schild, {Steven E} and Dirk Rades",
note = "Copyright{\textcopyright} 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.",
year = "2018",
month = jan,
doi = "10.21873/anticanres.12260",
language = "English",
volume = "38",
pages = "565--567",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1",

}

RIS

TY - JOUR

T1 - Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary

AU - Dziggel, Liesa

AU - Bajrovic, Amira

AU - Schild, Steven E

AU - Rades, Dirk

N1 - Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.RESULTS: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.CONCLUSION: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.

AB - BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.RESULTS: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.CONCLUSION: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.

KW - Brain Neoplasms

KW - Cranial Irradiation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms, Unknown Primary

KW - Radiosurgery

KW - Survival Rate

KW - Treatment Outcome

KW - Journal Article

U2 - 10.21873/anticanres.12260

DO - 10.21873/anticanres.12260

M3 - SCORING: Journal article

C2 - 29277825

VL - 38

SP - 565

EP - 567

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 1

ER -