Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary
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Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary. / Dziggel, Liesa; Bajrovic, Amira; Schild, Steven E; Rades, Dirk.
in: ANTICANCER RES, Jahrgang 38, Nr. 1, 01.2018, S. 565-567.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Stereotactic Radiosurgery Alone for One to Two Brain Metastases from Cancer of Unknown Primary
AU - Dziggel, Liesa
AU - Bajrovic, Amira
AU - Schild, Steven E
AU - Rades, Dirk
N1 - Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.RESULTS: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.CONCLUSION: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.
AB - BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation.PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival.RESULTS: Six-month and 12-month survival rates were 63% and 63%, respectively. Improved survival was associated with male gender and only one cerebral lesion. Local control rates at 6 and 12 months were 100%. Six-month rate of freedom from new cerebral lesions was 86%.CONCLUSION: SRS appeared effective and resulted in promising local control and survival rates in patients with 1-2 brain metastases from CUP.
KW - Brain Neoplasms
KW - Cranial Irradiation
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasms, Unknown Primary
KW - Radiosurgery
KW - Survival Rate
KW - Treatment Outcome
KW - Journal Article
U2 - 10.21873/anticanres.12260
DO - 10.21873/anticanres.12260
M3 - SCORING: Journal article
C2 - 29277825
VL - 38
SP - 565
EP - 567
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 1
ER -