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Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients

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Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients. / Saugel, B; Eschermann, K; Hoffmann, R; Hapfelmeier, A; Schultheiss, C; Phillip, V; Eyer, F; Laugwitz, K-L; Schmid, R M; Huber, W.

In: EUR J CLIN MICROBIOL, Vol. 31, No. 7, 01.07.2012, p. 1419-28.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Saugel, B, Eschermann, K, Hoffmann, R, Hapfelmeier, A, Schultheiss, C, Phillip, V, Eyer, F, Laugwitz, K-L, Schmid, RM & Huber, W 2012, 'Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients', EUR J CLIN MICROBIOL, vol. 31, no. 7, pp. 1419-28. https://doi.org/10.1007/s10096-011-1459-8

APA

Saugel, B., Eschermann, K., Hoffmann, R., Hapfelmeier, A., Schultheiss, C., Phillip, V., Eyer, F., Laugwitz, K-L., Schmid, R. M., & Huber, W. (2012). Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients. EUR J CLIN MICROBIOL, 31(7), 1419-28. https://doi.org/10.1007/s10096-011-1459-8

Vancouver

Saugel B, Eschermann K, Hoffmann R, Hapfelmeier A, Schultheiss C, Phillip V et al. Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients. EUR J CLIN MICROBIOL. 2012 Jul 1;31(7):1419-28. https://doi.org/10.1007/s10096-011-1459-8

Bibtex

@article{c540323aeabd45c5b5dd7252464f4bc7,
title = "Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients",
abstract = "The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p=0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p=0.009) and immunosuppression (p=0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p=0.040) and higher hospital mortality (p=0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p=0.001) and development of renal failure (p=0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.",
keywords = "Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Female, Gram-Negative Bacterial Infections, Humans, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Pneumonia, Bacterial, Respiratory System, Retrospective Studies, Risk Factors, Stenotrophomonas maltophilia, Survival Analysis",
author = "B Saugel and K Eschermann and R Hoffmann and A Hapfelmeier and C Schultheiss and V Phillip and F Eyer and K-L Laugwitz and Schmid, {R M} and W Huber",
year = "2012",
month = jul,
day = "1",
doi = "10.1007/s10096-011-1459-8",
language = "English",
volume = "31",
pages = "1419--28",
journal = "EUR J CLIN MICROBIOL",
issn = "0934-9723",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients

AU - Saugel, B

AU - Eschermann, K

AU - Hoffmann, R

AU - Hapfelmeier, A

AU - Schultheiss, C

AU - Phillip, V

AU - Eyer, F

AU - Laugwitz, K-L

AU - Schmid, R M

AU - Huber, W

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p=0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p=0.009) and immunosuppression (p=0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p=0.040) and higher hospital mortality (p=0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p=0.001) and development of renal failure (p=0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.

AB - The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p=0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p=0.009) and immunosuppression (p=0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p=0.040) and higher hospital mortality (p=0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p=0.001) and development of renal failure (p=0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Bacterial Agents

KW - Female

KW - Gram-Negative Bacterial Infections

KW - Humans

KW - Intensive Care Units

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Pneumonia, Bacterial

KW - Respiratory System

KW - Retrospective Studies

KW - Risk Factors

KW - Stenotrophomonas maltophilia

KW - Survival Analysis

U2 - 10.1007/s10096-011-1459-8

DO - 10.1007/s10096-011-1459-8

M3 - SCORING: Journal article

C2 - 22057419

VL - 31

SP - 1419

EP - 1428

JO - EUR J CLIN MICROBIOL

JF - EUR J CLIN MICROBIOL

SN - 0934-9723

IS - 7

ER -