Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients
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Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients. / Saugel, B; Eschermann, K; Hoffmann, R; Hapfelmeier, A; Schultheiss, C; Phillip, V; Eyer, F; Laugwitz, K-L; Schmid, R M; Huber, W.
in: EUR J CLIN MICROBIOL, Jahrgang 31, Nr. 7, 01.07.2012, S. 1419-28.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients
AU - Saugel, B
AU - Eschermann, K
AU - Hoffmann, R
AU - Hapfelmeier, A
AU - Schultheiss, C
AU - Phillip, V
AU - Eyer, F
AU - Laugwitz, K-L
AU - Schmid, R M
AU - Huber, W
PY - 2012/7/1
Y1 - 2012/7/1
N2 - The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p=0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p=0.009) and immunosuppression (p=0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p=0.040) and higher hospital mortality (p=0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p=0.001) and development of renal failure (p=0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.
AB - The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p=0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p=0.009) and immunosuppression (p=0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p=0.040) and higher hospital mortality (p=0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p=0.001) and development of renal failure (p=0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Anti-Bacterial Agents
KW - Female
KW - Gram-Negative Bacterial Infections
KW - Humans
KW - Intensive Care Units
KW - Male
KW - Microbial Sensitivity Tests
KW - Middle Aged
KW - Pneumonia, Bacterial
KW - Respiratory System
KW - Retrospective Studies
KW - Risk Factors
KW - Stenotrophomonas maltophilia
KW - Survival Analysis
U2 - 10.1007/s10096-011-1459-8
DO - 10.1007/s10096-011-1459-8
M3 - SCORING: Journal article
C2 - 22057419
VL - 31
SP - 1419
EP - 1428
JO - EUR J CLIN MICROBIOL
JF - EUR J CLIN MICROBIOL
SN - 0934-9723
IS - 7
ER -