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Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia

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Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia. / Baumgart, Lea; Barz, Melanie; Delbridge, Claire; Aftahy, Amir Kaywan; Janssen, Insa Katrin; Jost, Philipp J; Ryang, Yu-Mi; Meyer, Bernhard; Gempt, Jens.

In: CURR ONCOL, Vol. 29, No. 9, 29.08.2022, p. 6236-6244.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baumgart, L, Barz, M, Delbridge, C, Aftahy, AK, Janssen, IK, Jost, PJ, Ryang, Y-M, Meyer, B & Gempt, J 2022, 'Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia', CURR ONCOL, vol. 29, no. 9, pp. 6236-6244. https://doi.org/10.3390/curroncol29090490

APA

Baumgart, L., Barz, M., Delbridge, C., Aftahy, A. K., Janssen, I. K., Jost, P. J., Ryang, Y-M., Meyer, B., & Gempt, J. (2022). Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia. CURR ONCOL, 29(9), 6236-6244. https://doi.org/10.3390/curroncol29090490

Vancouver

Baumgart L, Barz M, Delbridge C, Aftahy AK, Janssen IK, Jost PJ et al. Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia. CURR ONCOL. 2022 Aug 29;29(9):6236-6244. https://doi.org/10.3390/curroncol29090490

Bibtex

@article{ab96f1c11e814dc38a135447af3c556f,
title = "Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia",
abstract = "(1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs and vertebrae. (2) Methods: Retrospective analysis of 114 patients (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments and surgical instability were the criteria for intervention in this cohort. Analysis was based on demographic data, Spinal Instability Neoplastic Score (SINS), location of the lesion, spinal levels of tumor involvement, surgical treatment, histopathological workup, adjuvant therapy, functional outcome, and overall survival (OS). (3) Results: The following surgical procedures were performed: posterior stabilization only in 9 patients, posterior stabilization and decompression without vertebral body replacement in 56 patients, tumor debulking and decompression only in 8 patients, anterior approach in combined approach without vertebral body replacement and without biopsy and/or without kyphoplasty in 33 patients, 3 patients received biopsies only, and 5 patients received kyphoplasty only. The histopathology diagnoses were MM in 94 cases and SBP in 20 cases. Median OS was 72 months (53.4-90.6 months). Preoperative KPSS was 80% (range 40-100%), the postoperative KPSS was 80% (range 50-100%). (4) Conclusions: Surgery for patients with plasma cell neoplasia is beneficial in case of neurological impairment and spinal instability. Moreover, we were able to show that patients with MM and a low number of spinal levels to be supplied have a better prognosis as well as a younger age at the time of the surgical intervention.",
keywords = "Female, Humans, Male, Multiple Myeloma/pathology, Plasma Cells/pathology, Plasmacytoma/pathology, Retrospective Studies, Spinal Neoplasms/pathology, Spine/pathology, Treatment Outcome",
author = "Lea Baumgart and Melanie Barz and Claire Delbridge and Aftahy, {Amir Kaywan} and Janssen, {Insa Katrin} and Jost, {Philipp J} and Yu-Mi Ryang and Bernhard Meyer and Jens Gempt",
year = "2022",
month = aug,
day = "29",
doi = "10.3390/curroncol29090490",
language = "English",
volume = "29",
pages = "6236--6244",
journal = "CURR ONCOL",
issn = "1198-0052",
publisher = "Multimed Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia

AU - Baumgart, Lea

AU - Barz, Melanie

AU - Delbridge, Claire

AU - Aftahy, Amir Kaywan

AU - Janssen, Insa Katrin

AU - Jost, Philipp J

AU - Ryang, Yu-Mi

AU - Meyer, Bernhard

AU - Gempt, Jens

PY - 2022/8/29

Y1 - 2022/8/29

N2 - (1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs and vertebrae. (2) Methods: Retrospective analysis of 114 patients (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments and surgical instability were the criteria for intervention in this cohort. Analysis was based on demographic data, Spinal Instability Neoplastic Score (SINS), location of the lesion, spinal levels of tumor involvement, surgical treatment, histopathological workup, adjuvant therapy, functional outcome, and overall survival (OS). (3) Results: The following surgical procedures were performed: posterior stabilization only in 9 patients, posterior stabilization and decompression without vertebral body replacement in 56 patients, tumor debulking and decompression only in 8 patients, anterior approach in combined approach without vertebral body replacement and without biopsy and/or without kyphoplasty in 33 patients, 3 patients received biopsies only, and 5 patients received kyphoplasty only. The histopathology diagnoses were MM in 94 cases and SBP in 20 cases. Median OS was 72 months (53.4-90.6 months). Preoperative KPSS was 80% (range 40-100%), the postoperative KPSS was 80% (range 50-100%). (4) Conclusions: Surgery for patients with plasma cell neoplasia is beneficial in case of neurological impairment and spinal instability. Moreover, we were able to show that patients with MM and a low number of spinal levels to be supplied have a better prognosis as well as a younger age at the time of the surgical intervention.

AB - (1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs and vertebrae. (2) Methods: Retrospective analysis of 114 patients (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments and surgical instability were the criteria for intervention in this cohort. Analysis was based on demographic data, Spinal Instability Neoplastic Score (SINS), location of the lesion, spinal levels of tumor involvement, surgical treatment, histopathological workup, adjuvant therapy, functional outcome, and overall survival (OS). (3) Results: The following surgical procedures were performed: posterior stabilization only in 9 patients, posterior stabilization and decompression without vertebral body replacement in 56 patients, tumor debulking and decompression only in 8 patients, anterior approach in combined approach without vertebral body replacement and without biopsy and/or without kyphoplasty in 33 patients, 3 patients received biopsies only, and 5 patients received kyphoplasty only. The histopathology diagnoses were MM in 94 cases and SBP in 20 cases. Median OS was 72 months (53.4-90.6 months). Preoperative KPSS was 80% (range 40-100%), the postoperative KPSS was 80% (range 50-100%). (4) Conclusions: Surgery for patients with plasma cell neoplasia is beneficial in case of neurological impairment and spinal instability. Moreover, we were able to show that patients with MM and a low number of spinal levels to be supplied have a better prognosis as well as a younger age at the time of the surgical intervention.

KW - Female

KW - Humans

KW - Male

KW - Multiple Myeloma/pathology

KW - Plasma Cells/pathology

KW - Plasmacytoma/pathology

KW - Retrospective Studies

KW - Spinal Neoplasms/pathology

KW - Spine/pathology

KW - Treatment Outcome

U2 - 10.3390/curroncol29090490

DO - 10.3390/curroncol29090490

M3 - SCORING: Journal article

C2 - 36135059

VL - 29

SP - 6236

EP - 6244

JO - CURR ONCOL

JF - CURR ONCOL

SN - 1198-0052

IS - 9

ER -