Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia
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Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia. / Baumgart, Lea; Barz, Melanie; Delbridge, Claire; Aftahy, Amir Kaywan; Janssen, Insa Katrin; Jost, Philipp J; Ryang, Yu-Mi; Meyer, Bernhard; Gempt, Jens.
in: CURR ONCOL, Jahrgang 29, Nr. 9, 29.08.2022, S. 6236-6244.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Spinal Lesions as Clinical Manifestations of Plasma Cell Neoplasia
AU - Baumgart, Lea
AU - Barz, Melanie
AU - Delbridge, Claire
AU - Aftahy, Amir Kaywan
AU - Janssen, Insa Katrin
AU - Jost, Philipp J
AU - Ryang, Yu-Mi
AU - Meyer, Bernhard
AU - Gempt, Jens
PY - 2022/8/29
Y1 - 2022/8/29
N2 - (1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs and vertebrae. (2) Methods: Retrospective analysis of 114 patients (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments and surgical instability were the criteria for intervention in this cohort. Analysis was based on demographic data, Spinal Instability Neoplastic Score (SINS), location of the lesion, spinal levels of tumor involvement, surgical treatment, histopathological workup, adjuvant therapy, functional outcome, and overall survival (OS). (3) Results: The following surgical procedures were performed: posterior stabilization only in 9 patients, posterior stabilization and decompression without vertebral body replacement in 56 patients, tumor debulking and decompression only in 8 patients, anterior approach in combined approach without vertebral body replacement and without biopsy and/or without kyphoplasty in 33 patients, 3 patients received biopsies only, and 5 patients received kyphoplasty only. The histopathology diagnoses were MM in 94 cases and SBP in 20 cases. Median OS was 72 months (53.4-90.6 months). Preoperative KPSS was 80% (range 40-100%), the postoperative KPSS was 80% (range 50-100%). (4) Conclusions: Surgery for patients with plasma cell neoplasia is beneficial in case of neurological impairment and spinal instability. Moreover, we were able to show that patients with MM and a low number of spinal levels to be supplied have a better prognosis as well as a younger age at the time of the surgical intervention.
AB - (1) Background: Plasma cell neoplasia can be separated into independent subtypes including multiple myeloma (MM) and solitary plasmacytoma of the bone (SBP). The first clinical signs patients present with are skeletal pain, most commonly involving ribs and vertebrae. (2) Methods: Retrospective analysis of 114 patients (38 female, 76 male) receiving spinal surgery from March 2006 until April 2020. Neurological impairments and surgical instability were the criteria for intervention in this cohort. Analysis was based on demographic data, Spinal Instability Neoplastic Score (SINS), location of the lesion, spinal levels of tumor involvement, surgical treatment, histopathological workup, adjuvant therapy, functional outcome, and overall survival (OS). (3) Results: The following surgical procedures were performed: posterior stabilization only in 9 patients, posterior stabilization and decompression without vertebral body replacement in 56 patients, tumor debulking and decompression only in 8 patients, anterior approach in combined approach without vertebral body replacement and without biopsy and/or without kyphoplasty in 33 patients, 3 patients received biopsies only, and 5 patients received kyphoplasty only. The histopathology diagnoses were MM in 94 cases and SBP in 20 cases. Median OS was 72 months (53.4-90.6 months). Preoperative KPSS was 80% (range 40-100%), the postoperative KPSS was 80% (range 50-100%). (4) Conclusions: Surgery for patients with plasma cell neoplasia is beneficial in case of neurological impairment and spinal instability. Moreover, we were able to show that patients with MM and a low number of spinal levels to be supplied have a better prognosis as well as a younger age at the time of the surgical intervention.
KW - Female
KW - Humans
KW - Male
KW - Multiple Myeloma/pathology
KW - Plasma Cells/pathology
KW - Plasmacytoma/pathology
KW - Retrospective Studies
KW - Spinal Neoplasms/pathology
KW - Spine/pathology
KW - Treatment Outcome
U2 - 10.3390/curroncol29090490
DO - 10.3390/curroncol29090490
M3 - SCORING: Journal article
C2 - 36135059
VL - 29
SP - 6236
EP - 6244
JO - CURR ONCOL
JF - CURR ONCOL
SN - 1198-0052
IS - 9
ER -