Somatotopic organization of human somatosensory cortices for pain

TY - JOUR

T1 - Somatotopic organization of human somatosensory cortices for pain

T2 - a single trial fMRI study

AU - Bingel, U

AU - Lorenz, J

AU - Glauche, V

AU - Knab, R

AU - Gläscher, J

AU - Weiller, C

AU - Büchel, C

PY - 2004/9/1

Y1 - 2004/9/1

N2 - The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.

AB - The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.

KW - Adult

KW - Afferent Pathways

KW - Brain Mapping

KW - Dominance, Cerebral

KW - Female

KW - Foot

KW - Functional Laterality

KW - Hand

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Lasers

KW - Magnetic Resonance Imaging

KW - Male

KW - Mechanoreceptors

KW - Nociceptors

KW - Orientation

KW - Pain Threshold

KW - Reference Values

KW - Skin

KW - Skin Temperature

KW - Somatosensory Cortex

KW - Touch

U2 - 10.1016/j.neuroimage.2004.05.021

DO - 10.1016/j.neuroimage.2004.05.021

M3 - SCORING: Journal article

C2 - 15325369

VL - 23

SP - 224

EP - 232

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

IS - 1

ER -