Somatotopic organization of human somatosensory cortices for pain
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Somatotopic organization of human somatosensory cortices for pain : a single trial fMRI study. / Bingel, U; Lorenz, J; Glauche, V; Knab, R; Gläscher, J; Weiller, C; Büchel, C.
in: NEUROIMAGE, Jahrgang 23, Nr. 1, 01.09.2004, S. 224-32.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Somatotopic organization of human somatosensory cortices for pain
T2 - a single trial fMRI study
AU - Bingel, U
AU - Lorenz, J
AU - Glauche, V
AU - Knab, R
AU - Gläscher, J
AU - Weiller, C
AU - Büchel, C
PY - 2004/9/1
Y1 - 2004/9/1
N2 - The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.
AB - The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. To investigate the somatotopic organization of the nociceptive system, we applied Thulium-YAG-laser evoked pain stimuli, which have no concomitant tactile component, to the dorsum of the left hand and foot in randomized order. We used single-trial functional magnetic resonance imaging (fMRI) to assess differential hemodynamic responses to hand and foot stimulation for the group and in a single subject approach. The primary somatosensory cortex (SI) shows a clear somatotopic organization ipsi- and contralaterally to painful stimulation. Furthermore, a differential representation of hand and foot stimulation appeared within the contralateral opercular--insular region of the secondary somatosensory cortex (SII). This result provides evidence that both SI and SII encode spatial information of nociceptive stimuli without additional information from the tactile system and highlights the concept of a redundant representation of basic discriminative stimulus features in human somatosensory cortices, which seems adequate in view of the evolutionary importance of pain perception.
KW - Adult
KW - Afferent Pathways
KW - Brain Mapping
KW - Dominance, Cerebral
KW - Female
KW - Foot
KW - Functional Laterality
KW - Hand
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Imaging, Three-Dimensional
KW - Lasers
KW - Magnetic Resonance Imaging
KW - Male
KW - Mechanoreceptors
KW - Nociceptors
KW - Orientation
KW - Pain Threshold
KW - Reference Values
KW - Skin
KW - Skin Temperature
KW - Somatosensory Cortex
KW - Touch
U2 - 10.1016/j.neuroimage.2004.05.021
DO - 10.1016/j.neuroimage.2004.05.021
M3 - SCORING: Journal article
C2 - 15325369
VL - 23
SP - 224
EP - 232
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 1
ER -