Somatic Development in Children with Congenital Heart Defects
Standard
Somatic Development in Children with Congenital Heart Defects. / Poryo, Martin; Paes, Laura Antonia; Pickardt, Thomas; Bauer, Ulrike M M; Meyer, Sascha; Wagenpfeil, Stefan; Abdul-Khaliq, Hashim; German Competence Network for Congenital Heart Defects Investigators.
In: J PEDIATR-US, Vol. 192, 01.2018, p. 136-143.e4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Somatic Development in Children with Congenital Heart Defects
AU - Poryo, Martin
AU - Paes, Laura Antonia
AU - Pickardt, Thomas
AU - Bauer, Ulrike M M
AU - Meyer, Sascha
AU - Wagenpfeil, Stefan
AU - Abdul-Khaliq, Hashim
AU - German Competence Network for Congenital Heart Defects Investigators
AU - Kozlik-Feldmann, Rainer
AU - Sachweh, Jörg Siegmar
AU - Riso, Arlindo
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - OBJECTIVES: Somatic development is impaired in children with congenital heart defects (CHDs), and head circumference seems to be a strong predictor of neurodevelopmental prognosis. The aim of this study was to generate up-to-date reference values for the somatic development (head circumference, body weight, and length/height) of children with CHDs.STUDY DESIGN: Our study population consisted of all patients included in the PAN study (Prävalenz angeborener Herzfehler bei Neugeborenen in Deutschland), which was conducted prospectively over a 3-year study period by the Competence Network for Congenital Heart Defects. All children with mild, moderate, and severe CHDs born in 2006-2009 in Germany were enrolled. For computing of z-scores, only children with the following characteristics were included: appropriate for gestational age, nonsyndromic disease, term or post-term delivery, and no cardiac surgery.RESULTS: There were 2818 patients included. New z-scores for the described somatic measures of children with mild, moderate, and severe CHDs were computed. Comparisons with the KiGGS study (Gesundheit von Kindern und Jugendlichen in Deutschland) and the Berlin Longitudinal Study revealed significantly lower measurements for all measures-most notably in children with severe CHDs and/or cardiac surgery. In our cohort, no catch-up growth was seen after cardiac surgery.CONCLUSION: Children with severe CHDs demonstrated the most abnormal pattern in growth, including head circumference before and after cardiac surgery, which is indicative of accompanying brain pathology unrelated to operative injury.
AB - OBJECTIVES: Somatic development is impaired in children with congenital heart defects (CHDs), and head circumference seems to be a strong predictor of neurodevelopmental prognosis. The aim of this study was to generate up-to-date reference values for the somatic development (head circumference, body weight, and length/height) of children with CHDs.STUDY DESIGN: Our study population consisted of all patients included in the PAN study (Prävalenz angeborener Herzfehler bei Neugeborenen in Deutschland), which was conducted prospectively over a 3-year study period by the Competence Network for Congenital Heart Defects. All children with mild, moderate, and severe CHDs born in 2006-2009 in Germany were enrolled. For computing of z-scores, only children with the following characteristics were included: appropriate for gestational age, nonsyndromic disease, term or post-term delivery, and no cardiac surgery.RESULTS: There were 2818 patients included. New z-scores for the described somatic measures of children with mild, moderate, and severe CHDs were computed. Comparisons with the KiGGS study (Gesundheit von Kindern und Jugendlichen in Deutschland) and the Berlin Longitudinal Study revealed significantly lower measurements for all measures-most notably in children with severe CHDs and/or cardiac surgery. In our cohort, no catch-up growth was seen after cardiac surgery.CONCLUSION: Children with severe CHDs demonstrated the most abnormal pattern in growth, including head circumference before and after cardiac surgery, which is indicative of accompanying brain pathology unrelated to operative injury.
KW - Body Height/physiology
KW - Body Weight/physiology
KW - Cephalometry
KW - Child Development/physiology
KW - Child, Preschool
KW - Female
KW - Head/growth & development
KW - Heart Defects, Congenital/physiopathology
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Linear Models
KW - Longitudinal Studies
KW - Male
KW - Prospective Studies
KW - Reference Values
U2 - 10.1016/j.jpeds.2017.09.059
DO - 10.1016/j.jpeds.2017.09.059
M3 - SCORING: Journal article
C2 - 29246335
VL - 192
SP - 136-143.e4
JO - J PEDIATR-US
JF - J PEDIATR-US
SN - 0022-3476
ER -