Skin barrier in atopic dermatitis
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Skin barrier in atopic dermatitis. / Kezic, Sanja; Novak, Natalija; Jakasa, Ivone; Jungersted, Jackob M; Simon, Michel; Brandner, Johanna M; Middelkamp-Hup, Maritza A; Weidinger, Stephan.
In: FRONT BIOSCI-LANDMRK, Vol. 19, 01.01.2014, p. 541-556.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Skin barrier in atopic dermatitis
AU - Kezic, Sanja
AU - Novak, Natalija
AU - Jakasa, Ivone
AU - Jungersted, Jackob M
AU - Simon, Michel
AU - Brandner, Johanna M
AU - Middelkamp-Hup, Maritza A
AU - Weidinger, Stephan
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.
AB - The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.
KW - Dermatitis, Atopic
KW - Humans
KW - Intermediate Filament Proteins
KW - Lipids
KW - Skin Absorption
KW - Tight Junctions
M3 - SCORING: Journal article
C2 - 24389202
VL - 19
SP - 541
EP - 556
JO - FRONT BIOSCI-LANDMRK
JF - FRONT BIOSCI-LANDMRK
SN - 2768-6701
ER -