Research ExplorerPublicationsSkeletal dissemination in Paget's disease of the spine

Skeletal dissemination in Paget's disease of the spine

Standard

Skeletal dissemination in Paget's disease of the spine. / Rolvien, Tim; Butscheidt, Sebastian; Zustin, Josef; Amling, Michael.

In: EUR SPINE J, Vol. 27, No. Suppl 3, 07.2018, p. 453-457.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rolvien, T, Butscheidt, S, Zustin, J & Amling, M 2018, 'Skeletal dissemination in Paget's disease of the spine', EUR SPINE J, vol. 27, no. Suppl 3, pp. 453-457. https://doi.org/10.1007/s00586-018-5477-4

APA

Rolvien, T., Butscheidt, S., Zustin, J., & Amling, M. (2018). Skeletal dissemination in Paget's disease of the spine. EUR SPINE J, 27(Suppl 3), 453-457. https://doi.org/10.1007/s00586-018-5477-4

Vancouver

Rolvien T, Butscheidt S, Zustin J, Amling M. Skeletal dissemination in Paget's disease of the spine. EUR SPINE J. 2018 Jul;27(Suppl 3):453-457. https://doi.org/10.1007/s00586-018-5477-4

Bibtex

@article{b6a184741e6d4bf68cdc4a683839557d,
title = "Skeletal dissemination in Paget's disease of the spine",
abstract = "PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.METHODS: Case report.RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.CONCLUSIONS: We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.",
keywords = "Journal Article, Review, Osteitis Deformans/drug therapy, Spine/pathology, Humans, Middle Aged, Postoperative Complications/drug therapy, Male, Tomography, X-Ray Computed, Alkaline Phosphatase/blood, Disease Progression, Diphosphonates/therapeutic use, Zoledronic Acid/therapeutic use, Iatrogenic Disease",
author = "Tim Rolvien and Sebastian Butscheidt and Josef Zustin and Michael Amling",
year = "2018",
month = jul,
doi = "10.1007/s00586-018-5477-4",
language = "English",
volume = "27",
pages = "453--457",
journal = "EUR SPINE J",
issn = "0940-6719",
publisher = "Springer",
number = "Suppl 3",

}

RIS

TY - JOUR

T1 - Skeletal dissemination in Paget's disease of the spine

AU - Rolvien, Tim

AU - Butscheidt, Sebastian

AU - Zustin, Josef

AU - Amling, Michael

PY - 2018/7

Y1 - 2018/7

N2 - PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.METHODS: Case report.RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.CONCLUSIONS: We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.

AB - PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.METHODS: Case report.RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.CONCLUSIONS: We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.

KW - Journal Article

KW - Review

KW - Osteitis Deformans/drug therapy

KW - Spine/pathology

KW - Humans

KW - Middle Aged

KW - Postoperative Complications/drug therapy

KW - Male

KW - Tomography, X-Ray Computed

KW - Alkaline Phosphatase/blood

KW - Disease Progression

KW - Diphosphonates/therapeutic use

KW - Zoledronic Acid/therapeutic use

KW - Iatrogenic Disease

U2 - 10.1007/s00586-018-5477-4

DO - 10.1007/s00586-018-5477-4

M3 - SCORING: Journal article

C2 - 29344730

VL - 27

SP - 453

EP - 457

JO - EUR SPINE J

JF - EUR SPINE J

SN - 0940-6719

IS - Suppl 3

ER -