Skeletal dissemination in Paget's disease of the spine
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Skeletal dissemination in Paget's disease of the spine. / Rolvien, Tim; Butscheidt, Sebastian; Zustin, Josef; Amling, Michael.
in: EUR SPINE J, Jahrgang 27, Nr. Suppl 3, 07.2018, S. 453-457.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Skeletal dissemination in Paget's disease of the spine
AU - Rolvien, Tim
AU - Butscheidt, Sebastian
AU - Zustin, Josef
AU - Amling, Michael
PY - 2018/7
Y1 - 2018/7
N2 - PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.METHODS: Case report.RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.CONCLUSIONS: We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.
AB - PURPOSE: Paget's disease of bone (PDB) is a common skeletal disorder that is associated with locally increased bone turnover, skeletal deformity and pain. We report a case of skeletal dissemination in PDB of the spine.METHODS: Case report.RESULTS: A 46-year-old former professional athlete suffered from disseminated PDB throughout the spine and hips after various surgical interventions including spondylodesis, bone grafting and bone morphogenetic protein (rhBMP-2) administration. Only intravenous zoledronic acid prevented the further progression of skeletal dissemination, which was expressed by a normalization of (bone-specific) alkaline phosphatase levels. The biopsy obtained from the lumbar spine confirmed the diagnosis of PDB in the absence of malignant transformation.CONCLUSIONS: We outline skeletal dissemination as a possibly surgery-related complication in a patient with PDB in the lumbar spine. Bisphosphonates remain the treatment of first choice in PDB and surgical interventions should be considered very carefully.
KW - Journal Article
KW - Review
KW - Osteitis Deformans/drug therapy
KW - Spine/pathology
KW - Humans
KW - Middle Aged
KW - Postoperative Complications/drug therapy
KW - Male
KW - Tomography, X-Ray Computed
KW - Alkaline Phosphatase/blood
KW - Disease Progression
KW - Diphosphonates/therapeutic use
KW - Zoledronic Acid/therapeutic use
KW - Iatrogenic Disease
U2 - 10.1007/s00586-018-5477-4
DO - 10.1007/s00586-018-5477-4
M3 - SCORING: Journal article
C2 - 29344730
VL - 27
SP - 453
EP - 457
JO - EUR SPINE J
JF - EUR SPINE J
SN - 0940-6719
IS - Suppl 3
ER -