Size matters: Grey matter brain reserve predicts executive functioning in the elderly

M Laubach; F Lammers; N Zacharias; I Feinkohl; T Pischon; F Borchers; A J C Slooter; S Kühn; C Spies; G Winterer; BioCog Consortium

doi:10.1016/j.neuropsychologia.2018.08.008

Size matters: Grey matter brain reserve predicts executive functioning in the elderly

Standard

Size matters: Grey matter brain reserve predicts executive functioning in the elderly. / Laubach, M; Lammers, F; Zacharias, N; Feinkohl, I; Pischon, T; Borchers, F; Slooter, A J C; Kühn, S; Spies, C; Winterer, G; BioCog Consortium.

In: NEUROPSYCHOLOGIA, Vol. 119, 10.2018, p. 172-181.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Laubach, M, Lammers, F, Zacharias, N, Feinkohl, I, Pischon, T, Borchers, F, Slooter, AJC, Kühn, S, Spies, C, Winterer, G & BioCog Consortium 2018, 'Size matters: Grey matter brain reserve predicts executive functioning in the elderly', NEUROPSYCHOLOGIA, vol. 119, pp. 172-181. https://doi.org/10.1016/j.neuropsychologia.2018.08.008

APA

Laubach, M., Lammers, F., Zacharias, N., Feinkohl, I., Pischon, T., Borchers, F., Slooter, A. J. C., Kühn, S., Spies, C., Winterer, G., & BioCog Consortium (2018). Size matters: Grey matter brain reserve predicts executive functioning in the elderly. NEUROPSYCHOLOGIA, 119, 172-181. https://doi.org/10.1016/j.neuropsychologia.2018.08.008

Vancouver

Laubach M, Lammers F, Zacharias N, Feinkohl I, Pischon T, Borchers F et al. Size matters: Grey matter brain reserve predicts executive functioning in the elderly. NEUROPSYCHOLOGIA. 2018 Oct;119:172-181. https://doi.org/10.1016/j.neuropsychologia.2018.08.008

Bibtex

@article{2fbee887068148019cfbd114d37dcc0e,

title = "Size matters: Grey matter brain reserve predicts executive functioning in the elderly",

abstract = "Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy ({\ss} = -0.201 to -0.275, p = 0.001-0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.",

keywords = "Journal Article",

author = "M Laubach and F Lammers and N Zacharias and I Feinkohl and T Pischon and F Borchers and Slooter, {A J C} and S K{\"u}hn and C Spies and G Winterer and {BioCog Consortium}",

year = "2018",

month = oct,

doi = "10.1016/j.neuropsychologia.2018.08.008",

language = "English",

volume = "119",

pages = "172--181",

journal = "NEUROPSYCHOLOGIA",

issn = "0028-3932",

publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Size matters: Grey matter brain reserve predicts executive functioning in the elderly

AU - Laubach, M

AU - Lammers, F

AU - Zacharias, N

AU - Feinkohl, I

AU - Pischon, T

AU - Borchers, F

AU - Slooter, A J C

AU - Kühn, S

AU - Spies, C

AU - Winterer, G

AU - BioCog Consortium

PY - 2018/10

Y1 - 2018/10

N2 - Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001-0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.

AB - Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001-0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.

KW - Journal Article

U2 - 10.1016/j.neuropsychologia.2018.08.008

DO - 10.1016/j.neuropsychologia.2018.08.008

M3 - SCORING: Journal article

C2 - 30102906

VL - 119

SP - 172

EP - 181

JO - NEUROPSYCHOLOGIA

JF - NEUROPSYCHOLOGIA

SN - 0028-3932

ER -