Size matters: Grey matter brain reserve predicts executive functioning in the elderly
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Size matters: Grey matter brain reserve predicts executive functioning in the elderly. / Laubach, M; Lammers, F; Zacharias, N; Feinkohl, I; Pischon, T; Borchers, F; Slooter, A J C; Kühn, S; Spies, C; Winterer, G; BioCog Consortium.
in: NEUROPSYCHOLOGIA, Jahrgang 119, 10.2018, S. 172-181.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Size matters: Grey matter brain reserve predicts executive functioning in the elderly
AU - Laubach, M
AU - Lammers, F
AU - Zacharias, N
AU - Feinkohl, I
AU - Pischon, T
AU - Borchers, F
AU - Slooter, A J C
AU - Kühn, S
AU - Spies, C
AU - Winterer, G
AU - BioCog Consortium
N1 - Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001-0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.
AB - Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001-0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly.
KW - Journal Article
U2 - 10.1016/j.neuropsychologia.2018.08.008
DO - 10.1016/j.neuropsychologia.2018.08.008
M3 - SCORING: Journal article
C2 - 30102906
VL - 119
SP - 172
EP - 181
JO - NEUROPSYCHOLOGIA
JF - NEUROPSYCHOLOGIA
SN - 0028-3932
ER -