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Signature of circulating microRNAs in osteoarthritis

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Signature of circulating microRNAs in osteoarthritis. / Beyer, Christian; Zampetaki, Anna; Lin, Neng-Yu; Kleyer, Arnd; Perricone, Carlo; Iagnocco, Annamaria; Distler, Alfiya; Langley, Sarah R; Gelse, Kolja; Sesselmann, Stefan; Lorenzini, Rolando; Niemeier, Andreas; Swoboda, Bernd; Distler, Jörg H W; Santer, Peter; Egger, Georg; Willeit, Johann; Mayr, Manuel; Schett, Georg; Kiechl, Stefan.

In: ANN RHEUM DIS, Vol. 74, No. 1, 01.03.2014, p. e18.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beyer, C, Zampetaki, A, Lin, N-Y, Kleyer, A, Perricone, C, Iagnocco, A, Distler, A, Langley, SR, Gelse, K, Sesselmann, S, Lorenzini, R, Niemeier, A, Swoboda, B, Distler, JHW, Santer, P, Egger, G, Willeit, J, Mayr, M, Schett, G & Kiechl, S 2014, 'Signature of circulating microRNAs in osteoarthritis', ANN RHEUM DIS, vol. 74, no. 1, pp. e18. https://doi.org/10.1136/annrheumdis-2013-204698

APA

Beyer, C., Zampetaki, A., Lin, N-Y., Kleyer, A., Perricone, C., Iagnocco, A., Distler, A., Langley, S. R., Gelse, K., Sesselmann, S., Lorenzini, R., Niemeier, A., Swoboda, B., Distler, J. H. W., Santer, P., Egger, G., Willeit, J., Mayr, M., Schett, G., & Kiechl, S. (2014). Signature of circulating microRNAs in osteoarthritis. ANN RHEUM DIS, 74(1), e18. https://doi.org/10.1136/annrheumdis-2013-204698

Vancouver

Beyer C, Zampetaki A, Lin N-Y, Kleyer A, Perricone C, Iagnocco A et al. Signature of circulating microRNAs in osteoarthritis. ANN RHEUM DIS. 2014 Mar 1;74(1):e18. https://doi.org/10.1136/annrheumdis-2013-204698

Bibtex

@article{f0a1428a098a484caea64a198e9d4bf0,
title = "Signature of circulating microRNAs in osteoarthritis",
abstract = "BACKGROUND: Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.METHODS: We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline.RESULTS: In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056).CONCLUSIONS: Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.",
author = "Christian Beyer and Anna Zampetaki and Neng-Yu Lin and Arnd Kleyer and Carlo Perricone and Annamaria Iagnocco and Alfiya Distler and Langley, {Sarah R} and Kolja Gelse and Stefan Sesselmann and Rolando Lorenzini and Andreas Niemeier and Bernd Swoboda and Distler, {J{\"o}rg H W} and Peter Santer and Georg Egger and Johann Willeit and Manuel Mayr and Georg Schett and Stefan Kiechl",
year = "2014",
month = mar,
day = "1",
doi = "10.1136/annrheumdis-2013-204698",
language = "English",
volume = "74",
pages = "e18",
journal = "ANN RHEUM DIS",
issn = "0003-4967",
publisher = "BMJ PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Signature of circulating microRNAs in osteoarthritis

AU - Beyer, Christian

AU - Zampetaki, Anna

AU - Lin, Neng-Yu

AU - Kleyer, Arnd

AU - Perricone, Carlo

AU - Iagnocco, Annamaria

AU - Distler, Alfiya

AU - Langley, Sarah R

AU - Gelse, Kolja

AU - Sesselmann, Stefan

AU - Lorenzini, Rolando

AU - Niemeier, Andreas

AU - Swoboda, Bernd

AU - Distler, Jörg H W

AU - Santer, Peter

AU - Egger, Georg

AU - Willeit, Johann

AU - Mayr, Manuel

AU - Schett, Georg

AU - Kiechl, Stefan

PY - 2014/3/1

Y1 - 2014/3/1

N2 - BACKGROUND: Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.METHODS: We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline.RESULTS: In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056).CONCLUSIONS: Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.

AB - BACKGROUND: Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.METHODS: We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline.RESULTS: In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056).CONCLUSIONS: Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.

U2 - 10.1136/annrheumdis-2013-204698

DO - 10.1136/annrheumdis-2013-204698

M3 - SCORING: Journal article

C2 - 24515954

VL - 74

SP - e18

JO - ANN RHEUM DIS

JF - ANN RHEUM DIS

SN - 0003-4967

IS - 1

ER -