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Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness

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Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness. / Valk, Sofie L; Xu, Ting; Margulies, Daniel S; Masouleh, Shahrzad Kharabian; Paquola, Casey; Goulas, Alexandros; Kochunov, Peter; Smallwood, Jonathan; Yeo, B T Thomas; Bernhardt, Boris C; Eickhoff, Simon B.

In: SCI ADV, Vol. 6, No. 39, 09.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Valk, SL, Xu, T, Margulies, DS, Masouleh, SK, Paquola, C, Goulas, A, Kochunov, P, Smallwood, J, Yeo, BTT, Bernhardt, BC & Eickhoff, SB 2020, 'Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness', SCI ADV, vol. 6, no. 39. https://doi.org/10.1126/sciadv.abb3417

APA

Valk, S. L., Xu, T., Margulies, D. S., Masouleh, S. K., Paquola, C., Goulas, A., Kochunov, P., Smallwood, J., Yeo, B. T. T., Bernhardt, B. C., & Eickhoff, S. B. (2020). Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness. SCI ADV, 6(39). https://doi.org/10.1126/sciadv.abb3417

Vancouver

Valk SL, Xu T, Margulies DS, Masouleh SK, Paquola C, Goulas A et al. Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness. SCI ADV. 2020 Sep;6(39). https://doi.org/10.1126/sciadv.abb3417

Bibtex

@article{0129d74c3790418e942795fb58208978,
title = "Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness",
abstract = "The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.",
author = "Valk, {Sofie L} and Ting Xu and Margulies, {Daniel S} and Masouleh, {Shahrzad Kharabian} and Casey Paquola and Alexandros Goulas and Peter Kochunov and Jonathan Smallwood and Yeo, {B T Thomas} and Bernhardt, {Boris C} and Eickhoff, {Simon B}",
note = "Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).",
year = "2020",
month = sep,
doi = "10.1126/sciadv.abb3417",
language = "English",
volume = "6",
journal = "SCI ADV",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "39",

}

RIS

TY - JOUR

T1 - Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness

AU - Valk, Sofie L

AU - Xu, Ting

AU - Margulies, Daniel S

AU - Masouleh, Shahrzad Kharabian

AU - Paquola, Casey

AU - Goulas, Alexandros

AU - Kochunov, Peter

AU - Smallwood, Jonathan

AU - Yeo, B T Thomas

AU - Bernhardt, Boris C

AU - Eickhoff, Simon B

N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

PY - 2020/9

Y1 - 2020/9

N2 - The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.

AB - The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.

U2 - 10.1126/sciadv.abb3417

DO - 10.1126/sciadv.abb3417

M3 - SCORING: Journal article

C2 - 32978162

VL - 6

JO - SCI ADV

JF - SCI ADV

SN - 2375-2548

IS - 39

ER -