Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness
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Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness. / Valk, Sofie L; Xu, Ting; Margulies, Daniel S; Masouleh, Shahrzad Kharabian; Paquola, Casey; Goulas, Alexandros; Kochunov, Peter; Smallwood, Jonathan; Yeo, B T Thomas; Bernhardt, Boris C; Eickhoff, Simon B.
in: SCI ADV, Jahrgang 6, Nr. 39, 09.2020.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness
AU - Valk, Sofie L
AU - Xu, Ting
AU - Margulies, Daniel S
AU - Masouleh, Shahrzad Kharabian
AU - Paquola, Casey
AU - Goulas, Alexandros
AU - Kochunov, Peter
AU - Smallwood, Jonathan
AU - Yeo, B T Thomas
AU - Bernhardt, Boris C
AU - Eickhoff, Simon B
N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
PY - 2020/9
Y1 - 2020/9
N2 - The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.
AB - The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describing a continuum of functions from basic processes involved in perception and action to more abstract features of human cognition. Together, our study provides important insights into how functional and evolutionary patterns converge at the level of macroscale cortical structural organization.
U2 - 10.1126/sciadv.abb3417
DO - 10.1126/sciadv.abb3417
M3 - SCORING: Journal article
C2 - 32978162
VL - 6
JO - SCI ADV
JF - SCI ADV
SN - 2375-2548
IS - 39
ER -