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Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation

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Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. / Higuchi, Satoshi; Orban, Mathias; Adamo, Marianna; Giannini, Cristina; Melica, Bruno; Karam, Nicole; Praz, Fabien; Kalbacher, Daniel; Lubos, Edith; Stolz, Lukas; Braun, Daniel; Näbauer, Michael; Wild, Mirjam; Doldi, Philipp; Neuss, Michael; Butter, Christian; Kassar, Mohammad; Ruf, Tobias; Petrescu, Aniela; Schofer, Niklas; Pfister, Roman; Iliadis, Christos; Unterhuber, Matthias; Thiele, Holger; Baldus, Stephan; von Bardeleben, Ralph Stephan; Massberg, Steffen; Windecker, Stephan; Lurz, Philipp; Petronio, Anna Sonia; Metra, Marco; Hausleiter, Jörg.

In: INT J CARDIOL, Vol. 371, 15.01.2023, p. 312-318.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Higuchi, S, Orban, M, Adamo, M, Giannini, C, Melica, B, Karam, N, Praz, F, Kalbacher, D, Lubos, E, Stolz, L, Braun, D, Näbauer, M, Wild, M, Doldi, P, Neuss, M, Butter, C, Kassar, M, Ruf, T, Petrescu, A, Schofer, N, Pfister, R, Iliadis, C, Unterhuber, M, Thiele, H, Baldus, S, von Bardeleben, RS, Massberg, S, Windecker, S, Lurz, P, Petronio, AS, Metra, M & Hausleiter, J 2023, 'Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation', INT J CARDIOL, vol. 371, pp. 312-318. https://doi.org/10.1016/j.ijcard.2022.09.028

APA

Higuchi, S., Orban, M., Adamo, M., Giannini, C., Melica, B., Karam, N., Praz, F., Kalbacher, D., Lubos, E., Stolz, L., Braun, D., Näbauer, M., Wild, M., Doldi, P., Neuss, M., Butter, C., Kassar, M., Ruf, T., Petrescu, A., ... Hausleiter, J. (2023). Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. INT J CARDIOL, 371, 312-318. https://doi.org/10.1016/j.ijcard.2022.09.028

Vancouver

Higuchi S, Orban M, Adamo M, Giannini C, Melica B, Karam N et al. Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. INT J CARDIOL. 2023 Jan 15;371:312-318. https://doi.org/10.1016/j.ijcard.2022.09.028

Bibtex

@article{7455f3e6486a4036b3874ebb18937dce,
title = "Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation",
abstract = "BACKGROUND: Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear.METHODS: EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality.RESULTS: The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003).CONCLUSIONS: Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients.",
keywords = "Humans, Male, Female, Middle Aged, Aged, Aged, 80 and over, Mitral Valve/surgery, Heart Valve Prosthesis Implantation/methods, Cardiac Catheterization/methods, Treatment Outcome, Mitral Valve Insufficiency/diagnosis, Heart Failure",
author = "Satoshi Higuchi and Mathias Orban and Marianna Adamo and Cristina Giannini and Bruno Melica and Nicole Karam and Fabien Praz and Daniel Kalbacher and Edith Lubos and Lukas Stolz and Daniel Braun and Michael N{\"a}bauer and Mirjam Wild and Philipp Doldi and Michael Neuss and Christian Butter and Mohammad Kassar and Tobias Ruf and Aniela Petrescu and Niklas Schofer and Roman Pfister and Christos Iliadis and Matthias Unterhuber and Holger Thiele and Stephan Baldus and {von Bardeleben}, {Ralph Stephan} and Steffen Massberg and Stephan Windecker and Philipp Lurz and Petronio, {Anna Sonia} and Marco Metra and J{\"o}rg Hausleiter",
note = "Copyright {\textcopyright} 2022 Elsevier B.V. All rights reserved.",
year = "2023",
month = jan,
day = "15",
doi = "10.1016/j.ijcard.2022.09.028",
language = "English",
volume = "371",
pages = "312--318",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation

AU - Higuchi, Satoshi

AU - Orban, Mathias

AU - Adamo, Marianna

AU - Giannini, Cristina

AU - Melica, Bruno

AU - Karam, Nicole

AU - Praz, Fabien

AU - Kalbacher, Daniel

AU - Lubos, Edith

AU - Stolz, Lukas

AU - Braun, Daniel

AU - Näbauer, Michael

AU - Wild, Mirjam

AU - Doldi, Philipp

AU - Neuss, Michael

AU - Butter, Christian

AU - Kassar, Mohammad

AU - Ruf, Tobias

AU - Petrescu, Aniela

AU - Schofer, Niklas

AU - Pfister, Roman

AU - Iliadis, Christos

AU - Unterhuber, Matthias

AU - Thiele, Holger

AU - Baldus, Stephan

AU - von Bardeleben, Ralph Stephan

AU - Massberg, Steffen

AU - Windecker, Stephan

AU - Lurz, Philipp

AU - Petronio, Anna Sonia

AU - Metra, Marco

AU - Hausleiter, Jörg

N1 - Copyright © 2022 Elsevier B.V. All rights reserved.

PY - 2023/1/15

Y1 - 2023/1/15

N2 - BACKGROUND: Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear.METHODS: EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality.RESULTS: The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003).CONCLUSIONS: Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients.

AB - BACKGROUND: Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear.METHODS: EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality.RESULTS: The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003).CONCLUSIONS: Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients.

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Aged

KW - Aged, 80 and over

KW - Mitral Valve/surgery

KW - Heart Valve Prosthesis Implantation/methods

KW - Cardiac Catheterization/methods

KW - Treatment Outcome

KW - Mitral Valve Insufficiency/diagnosis

KW - Heart Failure

U2 - 10.1016/j.ijcard.2022.09.028

DO - 10.1016/j.ijcard.2022.09.028

M3 - SCORING: Journal article

C2 - 36115443

VL - 371

SP - 312

EP - 318

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -