Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation
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Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation. / Higuchi, Satoshi; Orban, Mathias; Adamo, Marianna; Giannini, Cristina; Melica, Bruno; Karam, Nicole; Praz, Fabien; Kalbacher, Daniel; Lubos, Edith; Stolz, Lukas; Braun, Daniel; Näbauer, Michael; Wild, Mirjam; Doldi, Philipp; Neuss, Michael; Butter, Christian; Kassar, Mohammad; Ruf, Tobias; Petrescu, Aniela; Schofer, Niklas; Pfister, Roman; Iliadis, Christos; Unterhuber, Matthias; Thiele, Holger; Baldus, Stephan; von Bardeleben, Ralph Stephan; Massberg, Steffen; Windecker, Stephan; Lurz, Philipp; Petronio, Anna Sonia; Metra, Marco; Hausleiter, Jörg.
in: INT J CARDIOL, Jahrgang 371, 15.01.2023, S. 312-318.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation
AU - Higuchi, Satoshi
AU - Orban, Mathias
AU - Adamo, Marianna
AU - Giannini, Cristina
AU - Melica, Bruno
AU - Karam, Nicole
AU - Praz, Fabien
AU - Kalbacher, Daniel
AU - Lubos, Edith
AU - Stolz, Lukas
AU - Braun, Daniel
AU - Näbauer, Michael
AU - Wild, Mirjam
AU - Doldi, Philipp
AU - Neuss, Michael
AU - Butter, Christian
AU - Kassar, Mohammad
AU - Ruf, Tobias
AU - Petrescu, Aniela
AU - Schofer, Niklas
AU - Pfister, Roman
AU - Iliadis, Christos
AU - Unterhuber, Matthias
AU - Thiele, Holger
AU - Baldus, Stephan
AU - von Bardeleben, Ralph Stephan
AU - Massberg, Steffen
AU - Windecker, Stephan
AU - Lurz, Philipp
AU - Petronio, Anna Sonia
AU - Metra, Marco
AU - Hausleiter, Jörg
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2023/1/15
Y1 - 2023/1/15
N2 - BACKGROUND: Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear.METHODS: EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality.RESULTS: The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003).CONCLUSIONS: Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients.
AB - BACKGROUND: Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear.METHODS: EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality.RESULTS: The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003).CONCLUSIONS: Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients.
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Aged
KW - Aged, 80 and over
KW - Mitral Valve/surgery
KW - Heart Valve Prosthesis Implantation/methods
KW - Cardiac Catheterization/methods
KW - Treatment Outcome
KW - Mitral Valve Insufficiency/diagnosis
KW - Heart Failure
U2 - 10.1016/j.ijcard.2022.09.028
DO - 10.1016/j.ijcard.2022.09.028
M3 - SCORING: Journal article
C2 - 36115443
VL - 371
SP - 312
EP - 318
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
ER -