Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation
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Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. / Park, Sang-Don; Orban, Mathias; Karam, Nicole; Lubos, Edith; Kalbacher, Daniel; Braun, Daniel; Stolz, Lukas; Neuss, Michael; Butter, Christian; Praz, Fabien; Kassar, Mohammad; Petrescu, Aniela; Pfister, Roman; Iliadis, Christos; Unterhuber, Matthias; Lurz, Philipp; Thiele, Holger; Baldus, Stephan; von Bardeleben, Stephan; Blankenberg, Stefan; Massberg, Steffen; Windecker, Stephan; Hausleiter, Jörg; EuroSMR Investigators.
In: JACC-CARDIOVASC INTE, Vol. 14, No. 8, 26.04.2021, p. 819-827.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation
AU - Park, Sang-Don
AU - Orban, Mathias
AU - Karam, Nicole
AU - Lubos, Edith
AU - Kalbacher, Daniel
AU - Braun, Daniel
AU - Stolz, Lukas
AU - Neuss, Michael
AU - Butter, Christian
AU - Praz, Fabien
AU - Kassar, Mohammad
AU - Petrescu, Aniela
AU - Pfister, Roman
AU - Iliadis, Christos
AU - Unterhuber, Matthias
AU - Lurz, Philipp
AU - Thiele, Holger
AU - Baldus, Stephan
AU - von Bardeleben, Stephan
AU - Blankenberg, Stefan
AU - Massberg, Steffen
AU - Windecker, Stephan
AU - Hausleiter, Jörg
AU - EuroSMR Investigators
N1 - Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2021/4/26
Y1 - 2021/4/26
N2 - OBJECTIVES: The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).BACKGROUND: Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.METHODS: The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).RESULTS: A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.CONCLUSIONS: Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.
AB - OBJECTIVES: The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).BACKGROUND: Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.METHODS: The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).RESULTS: A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.CONCLUSIONS: Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.
KW - Echocardiography
KW - Female
KW - Heart Failure/diagnostic imaging
KW - Heart Valve Prosthesis Implantation
KW - Humans
KW - Male
KW - Mitral Valve Insufficiency/diagnostic imaging
KW - Quality of Life
KW - Treatment Outcome
U2 - 10.1016/j.jcin.2020.12.042
DO - 10.1016/j.jcin.2020.12.042
M3 - SCORING: Journal article
C2 - 33812815
VL - 14
SP - 819
EP - 827
JO - JACC-CARDIOVASC INTE
JF - JACC-CARDIOVASC INTE
SN - 1936-8798
IS - 8
ER -