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Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation

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Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. / Park, Sang-Don; Orban, Mathias; Karam, Nicole; Lubos, Edith; Kalbacher, Daniel; Braun, Daniel; Stolz, Lukas; Neuss, Michael; Butter, Christian; Praz, Fabien; Kassar, Mohammad; Petrescu, Aniela; Pfister, Roman; Iliadis, Christos; Unterhuber, Matthias; Lurz, Philipp; Thiele, Holger; Baldus, Stephan; von Bardeleben, Stephan; Blankenberg, Stefan; Massberg, Steffen; Windecker, Stephan; Hausleiter, Jörg; EuroSMR Investigators.

in: JACC-CARDIOVASC INTE, Jahrgang 14, Nr. 8, 26.04.2021, S. 819-827.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Park, S-D, Orban, M, Karam, N, Lubos, E, Kalbacher, D, Braun, D, Stolz, L, Neuss, M, Butter, C, Praz, F, Kassar, M, Petrescu, A, Pfister, R, Iliadis, C, Unterhuber, M, Lurz, P, Thiele, H, Baldus, S, von Bardeleben, S, Blankenberg, S, Massberg, S, Windecker, S, Hausleiter, J & EuroSMR Investigators 2021, 'Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation', JACC-CARDIOVASC INTE, Jg. 14, Nr. 8, S. 819-827. https://doi.org/10.1016/j.jcin.2020.12.042

APA

Park, S-D., Orban, M., Karam, N., Lubos, E., Kalbacher, D., Braun, D., Stolz, L., Neuss, M., Butter, C., Praz, F., Kassar, M., Petrescu, A., Pfister, R., Iliadis, C., Unterhuber, M., Lurz, P., Thiele, H., Baldus, S., von Bardeleben, S., ... EuroSMR Investigators (2021). Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. JACC-CARDIOVASC INTE, 14(8), 819-827. https://doi.org/10.1016/j.jcin.2020.12.042

Vancouver

Park S-D, Orban M, Karam N, Lubos E, Kalbacher D, Braun D et al. Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. JACC-CARDIOVASC INTE. 2021 Apr 26;14(8):819-827. https://doi.org/10.1016/j.jcin.2020.12.042

Bibtex

@article{3c2b02378bd44e2497e417281a04ee8e,
title = "Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation",
abstract = "OBJECTIVES: The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).BACKGROUND: Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.METHODS: The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).RESULTS: A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.CONCLUSIONS: Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.",
keywords = "Echocardiography, Female, Heart Failure/diagnostic imaging, Heart Valve Prosthesis Implantation, Humans, Male, Mitral Valve Insufficiency/diagnostic imaging, Quality of Life, Treatment Outcome",
author = "Sang-Don Park and Mathias Orban and Nicole Karam and Edith Lubos and Daniel Kalbacher and Daniel Braun and Lukas Stolz and Michael Neuss and Christian Butter and Fabien Praz and Mohammad Kassar and Aniela Petrescu and Roman Pfister and Christos Iliadis and Matthias Unterhuber and Philipp Lurz and Holger Thiele and Stephan Baldus and {von Bardeleben}, Stephan and Stefan Blankenberg and Steffen Massberg and Stephan Windecker and J{\"o}rg Hausleiter and {EuroSMR Investigators}",
note = "Copyright {\textcopyright} 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = apr,
day = "26",
doi = "10.1016/j.jcin.2020.12.042",
language = "English",
volume = "14",
pages = "819--827",
journal = "JACC-CARDIOVASC INTE",
issn = "1936-8798",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation

AU - Park, Sang-Don

AU - Orban, Mathias

AU - Karam, Nicole

AU - Lubos, Edith

AU - Kalbacher, Daniel

AU - Braun, Daniel

AU - Stolz, Lukas

AU - Neuss, Michael

AU - Butter, Christian

AU - Praz, Fabien

AU - Kassar, Mohammad

AU - Petrescu, Aniela

AU - Pfister, Roman

AU - Iliadis, Christos

AU - Unterhuber, Matthias

AU - Lurz, Philipp

AU - Thiele, Holger

AU - Baldus, Stephan

AU - von Bardeleben, Stephan

AU - Blankenberg, Stefan

AU - Massberg, Steffen

AU - Windecker, Stephan

AU - Hausleiter, Jörg

AU - EuroSMR Investigators

N1 - Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2021/4/26

Y1 - 2021/4/26

N2 - OBJECTIVES: The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).BACKGROUND: Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.METHODS: The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).RESULTS: A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.CONCLUSIONS: Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.

AB - OBJECTIVES: The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).BACKGROUND: Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.METHODS: The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).RESULTS: A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.CONCLUSIONS: Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.

KW - Echocardiography

KW - Female

KW - Heart Failure/diagnostic imaging

KW - Heart Valve Prosthesis Implantation

KW - Humans

KW - Male

KW - Mitral Valve Insufficiency/diagnostic imaging

KW - Quality of Life

KW - Treatment Outcome

U2 - 10.1016/j.jcin.2020.12.042

DO - 10.1016/j.jcin.2020.12.042

M3 - SCORING: Journal article

C2 - 33812815

VL - 14

SP - 819

EP - 827

JO - JACC-CARDIOVASC INTE

JF - JACC-CARDIOVASC INTE

SN - 1936-8798

IS - 8

ER -