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Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior

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Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. / Hu, Chun; Petersen, Meike; Hoyer, Nina; Spitzweck, Bettina; Tenedini, Federico; Wang, Denan; Gruschka, Alisa; Burchardt, Lara S; Szpotowicz, Emanuela; Schweizer, Michaela; Guntur, Ananya R; Yang, Chung-Hui; Soba, Peter.

In: NAT NEUROSCI, Vol. 20, No. 8, 08.2017, p. 1085-1095.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hu, C, Petersen, M, Hoyer, N, Spitzweck, B, Tenedini, F, Wang, D, Gruschka, A, Burchardt, LS, Szpotowicz, E, Schweizer, M, Guntur, AR, Yang, C-H & Soba, P 2017, 'Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior', NAT NEUROSCI, vol. 20, no. 8, pp. 1085-1095. https://doi.org/10.1038/nn.4580

APA

Hu, C., Petersen, M., Hoyer, N., Spitzweck, B., Tenedini, F., Wang, D., Gruschka, A., Burchardt, L. S., Szpotowicz, E., Schweizer, M., Guntur, A. R., Yang, C-H., & Soba, P. (2017). Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. NAT NEUROSCI, 20(8), 1085-1095. https://doi.org/10.1038/nn.4580

Vancouver

Hu C, Petersen M, Hoyer N, Spitzweck B, Tenedini F, Wang D et al. Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. NAT NEUROSCI. 2017 Aug;20(8):1085-1095. https://doi.org/10.1038/nn.4580

Bibtex

@article{c57871b9a8974711aa23e7a5790a5c6f,
title = "Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior",
abstract = "Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception. Notably, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required for robust mechanonociceptive responses. We further show that neurons integrating mechanosensory input facilitate primary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog. Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior.",
keywords = "Journal Article, POM-Newsletter",
author = "Chun Hu and Meike Petersen and Nina Hoyer and Bettina Spitzweck and Federico Tenedini and Denan Wang and Alisa Gruschka and Burchardt, {Lara S} and Emanuela Szpotowicz and Michaela Schweizer and Guntur, {Ananya R} and Chung-Hui Yang and Peter Soba",
year = "2017",
month = aug,
doi = "10.1038/nn.4580",
language = "English",
volume = "20",
pages = "1085--1095",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior

AU - Hu, Chun

AU - Petersen, Meike

AU - Hoyer, Nina

AU - Spitzweck, Bettina

AU - Tenedini, Federico

AU - Wang, Denan

AU - Gruschka, Alisa

AU - Burchardt, Lara S

AU - Szpotowicz, Emanuela

AU - Schweizer, Michaela

AU - Guntur, Ananya R

AU - Yang, Chung-Hui

AU - Soba, Peter

PY - 2017/8

Y1 - 2017/8

N2 - Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception. Notably, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required for robust mechanonociceptive responses. We further show that neurons integrating mechanosensory input facilitate primary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog. Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior.

AB - Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception. Notably, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required for robust mechanonociceptive responses. We further show that neurons integrating mechanosensory input facilitate primary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog. Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior.

KW - Journal Article

KW - POM-Newsletter

U2 - 10.1038/nn.4580

DO - 10.1038/nn.4580

M3 - SCORING: Journal article

C2 - 28604684

VL - 20

SP - 1085

EP - 1095

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 8

ER -