Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior
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Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. / Hu, Chun; Petersen, Meike; Hoyer, Nina; Spitzweck, Bettina; Tenedini, Federico; Wang, Denan; Gruschka, Alisa; Burchardt, Lara S; Szpotowicz, Emanuela; Schweizer, Michaela; Guntur, Ananya R; Yang, Chung-Hui; Soba, Peter.
in: NAT NEUROSCI, Jahrgang 20, Nr. 8, 08.2017, S. 1085-1095.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior
AU - Hu, Chun
AU - Petersen, Meike
AU - Hoyer, Nina
AU - Spitzweck, Bettina
AU - Tenedini, Federico
AU - Wang, Denan
AU - Gruschka, Alisa
AU - Burchardt, Lara S
AU - Szpotowicz, Emanuela
AU - Schweizer, Michaela
AU - Guntur, Ananya R
AU - Yang, Chung-Hui
AU - Soba, Peter
PY - 2017/8
Y1 - 2017/8
N2 - Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception. Notably, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required for robust mechanonociceptive responses. We further show that neurons integrating mechanosensory input facilitate primary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog. Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior.
AB - Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with stereotyped escape responses through activation of multimodal nociceptors. How behavioral responses to these different modalities are processed and integrated by the downstream network remains poorly understood. By combining trans-synaptic labeling, ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociception. Notably, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required for robust mechanonociceptive responses. We further show that neurons integrating mechanosensory input facilitate primary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog. Our findings unveil how integration of somatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape behavior.
KW - Journal Article
KW - POM-Newsletter
U2 - 10.1038/nn.4580
DO - 10.1038/nn.4580
M3 - SCORING: Journal article
C2 - 28604684
VL - 20
SP - 1085
EP - 1095
JO - NAT NEUROSCI
JF - NAT NEUROSCI
SN - 1097-6256
IS - 8
ER -