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Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up

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Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up. / Heeger, Christian-Hendrik; Subin, Behnam; Wissner, Erik; Fink, Thomas; Mathew, Shibu; Maurer, Tilman; Lemes, Christine; Rillig, Andreas; Wohlmuth, Peter; Reissmann, Bruno; Tilz, Roland Richard; Ouyang, Feifan; Kuck, Karl-Heinz; Metzner, Andreas.

In: INT J CARDIOL, Vol. 312, 01.08.2020, p. 73-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heeger, C-H, Subin, B, Wissner, E, Fink, T, Mathew, S, Maurer, T, Lemes, C, Rillig, A, Wohlmuth, P, Reissmann, B, Tilz, RR, Ouyang, F, Kuck, K-H & Metzner, A 2020, 'Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up', INT J CARDIOL, vol. 312, pp. 73-80. https://doi.org/10.1016/j.ijcard.2020.03.062

APA

Heeger, C-H., Subin, B., Wissner, E., Fink, T., Mathew, S., Maurer, T., Lemes, C., Rillig, A., Wohlmuth, P., Reissmann, B., Tilz, R. R., Ouyang, F., Kuck, K-H., & Metzner, A. (2020). Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up. INT J CARDIOL, 312, 73-80. https://doi.org/10.1016/j.ijcard.2020.03.062

Vancouver

Heeger C-H, Subin B, Wissner E, Fink T, Mathew S, Maurer T et al. Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up. INT J CARDIOL. 2020 Aug 1;312:73-80. https://doi.org/10.1016/j.ijcard.2020.03.062

Bibtex

@article{5fb4a5c9cc7943b3ab497bb3a4dfe5d2,
title = "Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up",
abstract = "BACKGROUND: Pulmonary vein isolation (PVI) using the second-generation cryoballoon (CB2) for atrial fibrillation (AF) treatment has demonstrated encouraging procedural success rates and mid-term results. However, long-term follow-up data on outcome is sparse. The current study is reporting on five-year clinical outcomes following CB2-based PVI in patients with paroxysmal AF (PAF) and persistent AF (PersAF).METHODS: A total of 139 patients underwent index CB2-based PVI patients (PAF: n = 105, 76% and PersAF: n = 34, 34%) in two electrophysiology centers. Freeze-cycle duration was 240 s. After successful PVI a bonus freeze-cycle of the same duration was applied in the first 71 patients while the bonus-freeze was omitted in 68 following patients. Three patients (2.2%) were lost to follow-up.RESULTS: After a median follow-up duration of 60 months (interquartile range: 46, 72 months) 74/136 (54.4%) patients remained in stable sinus rhythm (PAF: 62/104, 59.6%; PersAF: 15/32, 46.9%). Significant differences were observed concerning 5-year clinical outcome between PAF and PersAF patients (p = 0.0315). After a mean of 1.32 ± 0.6 procedures (2nd and 3rd procedure by radiofrequency ablation) and a median follow-up duration of 60 (37, 68) months 90/136 (66.2%) patients remained in stable sinus rhythm (PAF: 72/104 (69.2%), PersAF: 21/32 (65.6%), p = 0.0276). For the comparison of bonus-freeze vs no-bonus-freeze protocols no differences were observed (53.5% vs 57.4%, p = 0.650).CONCLUSIONS: The five-year single-procedure success rate for CB2-based PVI was 54.4% and increased to 66.2% following repeat RF-based procedures. No differences were detected comparing bonus-freeze and no-bonus-freeze protocols.",
keywords = "Atrial Fibrillation/diagnostic imaging, Catheter Ablation, Cryosurgery, Follow-Up Studies, Humans, Pulmonary Veins/diagnostic imaging, Recurrence, Time Factors, Treatment Outcome",
author = "Christian-Hendrik Heeger and Behnam Subin and Erik Wissner and Thomas Fink and Shibu Mathew and Tilman Maurer and Christine Lemes and Andreas Rillig and Peter Wohlmuth and Bruno Reissmann and Tilz, {Roland Richard} and Feifan Ouyang and Karl-Heinz Kuck and Andreas Metzner",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = aug,
day = "1",
doi = "10.1016/j.ijcard.2020.03.062",
language = "English",
volume = "312",
pages = "73--80",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up

AU - Heeger, Christian-Hendrik

AU - Subin, Behnam

AU - Wissner, Erik

AU - Fink, Thomas

AU - Mathew, Shibu

AU - Maurer, Tilman

AU - Lemes, Christine

AU - Rillig, Andreas

AU - Wohlmuth, Peter

AU - Reissmann, Bruno

AU - Tilz, Roland Richard

AU - Ouyang, Feifan

AU - Kuck, Karl-Heinz

AU - Metzner, Andreas

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - BACKGROUND: Pulmonary vein isolation (PVI) using the second-generation cryoballoon (CB2) for atrial fibrillation (AF) treatment has demonstrated encouraging procedural success rates and mid-term results. However, long-term follow-up data on outcome is sparse. The current study is reporting on five-year clinical outcomes following CB2-based PVI in patients with paroxysmal AF (PAF) and persistent AF (PersAF).METHODS: A total of 139 patients underwent index CB2-based PVI patients (PAF: n = 105, 76% and PersAF: n = 34, 34%) in two electrophysiology centers. Freeze-cycle duration was 240 s. After successful PVI a bonus freeze-cycle of the same duration was applied in the first 71 patients while the bonus-freeze was omitted in 68 following patients. Three patients (2.2%) were lost to follow-up.RESULTS: After a median follow-up duration of 60 months (interquartile range: 46, 72 months) 74/136 (54.4%) patients remained in stable sinus rhythm (PAF: 62/104, 59.6%; PersAF: 15/32, 46.9%). Significant differences were observed concerning 5-year clinical outcome between PAF and PersAF patients (p = 0.0315). After a mean of 1.32 ± 0.6 procedures (2nd and 3rd procedure by radiofrequency ablation) and a median follow-up duration of 60 (37, 68) months 90/136 (66.2%) patients remained in stable sinus rhythm (PAF: 72/104 (69.2%), PersAF: 21/32 (65.6%), p = 0.0276). For the comparison of bonus-freeze vs no-bonus-freeze protocols no differences were observed (53.5% vs 57.4%, p = 0.650).CONCLUSIONS: The five-year single-procedure success rate for CB2-based PVI was 54.4% and increased to 66.2% following repeat RF-based procedures. No differences were detected comparing bonus-freeze and no-bonus-freeze protocols.

AB - BACKGROUND: Pulmonary vein isolation (PVI) using the second-generation cryoballoon (CB2) for atrial fibrillation (AF) treatment has demonstrated encouraging procedural success rates and mid-term results. However, long-term follow-up data on outcome is sparse. The current study is reporting on five-year clinical outcomes following CB2-based PVI in patients with paroxysmal AF (PAF) and persistent AF (PersAF).METHODS: A total of 139 patients underwent index CB2-based PVI patients (PAF: n = 105, 76% and PersAF: n = 34, 34%) in two electrophysiology centers. Freeze-cycle duration was 240 s. After successful PVI a bonus freeze-cycle of the same duration was applied in the first 71 patients while the bonus-freeze was omitted in 68 following patients. Three patients (2.2%) were lost to follow-up.RESULTS: After a median follow-up duration of 60 months (interquartile range: 46, 72 months) 74/136 (54.4%) patients remained in stable sinus rhythm (PAF: 62/104, 59.6%; PersAF: 15/32, 46.9%). Significant differences were observed concerning 5-year clinical outcome between PAF and PersAF patients (p = 0.0315). After a mean of 1.32 ± 0.6 procedures (2nd and 3rd procedure by radiofrequency ablation) and a median follow-up duration of 60 (37, 68) months 90/136 (66.2%) patients remained in stable sinus rhythm (PAF: 72/104 (69.2%), PersAF: 21/32 (65.6%), p = 0.0276). For the comparison of bonus-freeze vs no-bonus-freeze protocols no differences were observed (53.5% vs 57.4%, p = 0.650).CONCLUSIONS: The five-year single-procedure success rate for CB2-based PVI was 54.4% and increased to 66.2% following repeat RF-based procedures. No differences were detected comparing bonus-freeze and no-bonus-freeze protocols.

KW - Atrial Fibrillation/diagnostic imaging

KW - Catheter Ablation

KW - Cryosurgery

KW - Follow-Up Studies

KW - Humans

KW - Pulmonary Veins/diagnostic imaging

KW - Recurrence

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2020.03.062

DO - 10.1016/j.ijcard.2020.03.062

M3 - SCORING: Journal article

C2 - 32241572

VL - 312

SP - 73

EP - 80

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -